Tert-butyl 4-[[1-[(6-methyl-3-phenylmethoxypyridin-2-yl)methyl]benzimidazol-2-yl]amino]piperidine-1-carboxylate | 910447-11-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: Tert-butyl 4-[[1-[(6-methyl-3-phenylmethoxypyridin-2-yl)methyl]benzimidazol-2-yl]amino]piperidine-1-carboxylate
• CAS: 910447-11-9
• 化学式: C₃₁H₃₇N₅O₃
• 分子量: 527.666
• InChiKey: DYTBQHNRSWWRAP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.6
• 重原子数：
  39
• 可旋转键数：
  9
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  81.5
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  Tert-butyl 4-[[1-[(6-methyl-3-phenylmethoxypyridin-2-yl)methyl]benzimidazol-2-yl]amino]piperidine-1-carboxylate 、 对氰基溴化苄 在 potassium iodide potassium carbonate 作用下， 以 乙腈 为溶剂， 反应 6.0h， 以31%的产率得到Tert-butyl 4-[[1-[(4-cyanophenyl)methyl]-3-[(6-methyl-3-phenylmethoxypyridin-2-yl)methyl]benzimidazol-2-ylidene]amino]piperidine-1-carboxylate
  参考文献：
  名称：

  WO2006/97534

  摘要：

  公开号：
• 作为产物：
  描述：

  3-benzyloxy-2-chloromethyl-6-methyl-pyridine 、 4-N-Boc-((1H-benzo[d]imidazol-2-yl)amino)piperidine 在 potassium carbonate 作用下， 以 乙腈 为溶剂， 反应 12.0h， 以100%的产率得到Tert-butyl 4-[[1-[(6-methyl-3-phenylmethoxypyridin-2-yl)methyl]benzimidazol-2-yl]amino]piperidine-1-carboxylate
  参考文献：
  名称：

  WO2006/97534

  摘要：

  公开号：

文献信息

• 1,3-Dihydro-Benzimidazol-2-Ylidene Amines as Inhibitors of Respiratory Syncytial Virus Replication
  申请人：Bonfanti Jean-Francois

  公开号：US20080146564A1

  公开（公告）日：2008-06-19

  Novel 1,3-dihydro-benzimidazol-2-ylidene amine derivatives of formula the addition salts and stereochemically isomeric forms wherein each Alk is C 1-6 alkanediyl; Q is hydrogen; C 1-6 alkyl substituted with one or two Ar 2 radicals; CI 1-6 alkyl substituted with quinolinyl, oxazolidinyl, thiazolidinyl, morpholinyl, thiomorpholinyl, or with pyrrolidinonyl; —CO—Ar 2 ; or Q is a radical of formula wherein t is 1, 2 or 3; R 4 is amino, mono- or di(C 1-6 alkyl)amino; R 1 is Ar 2 , —CO—Ar 2 or a monocyclic or bicyclic heterocycle which may optionally be substituted; R 2 is as R 1 and additionally can be hydrogen; where Q is other than hydrogen, R 3 is hydrogen; and where Q is other than hydrogen, R 3 is a radical: wherein R 6 is hydrogen, C 1-6 alkyl, substituted C 1-6 alkyl; R 7 , R 8 , R 9 are halo, cyano, C 1-6 alkyl, substituted C 1-6 alkyl, C 2-6 alkenyl, cyanoC 2-6 alkenyl, C 2-6 alkynyl, cyanoC 2 6 alkynyl, Ar 1 , R 10a —0—, R 10a —S—, —N(R 5a R 5b ), R 10a —O—C(═O)—, N(R 5a R 5b )—C(═O)—, R 10a —C(═O)—NR 5b 1', R 10b —C(═O)—O—; and R 8 and/or R 9 may also be hydrogen; which are RSV inhibitors. Compositions containing these compounds and processes for preparing these compounds and compositions.
• US7956196B2
  申请人：——

  公开号：US7956196B2

  公开（公告）日：2011-06-07
• WO2006/97534
  申请人：——

  公开号：——

  公开（公告）日：——