3-(4'-Cyclohexanon) (1H)-inden | 66248-90-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 菲及其衍生物
• 英文名称: 3-(4'-Cyclohexanon) (1H)-inden
• 英文别名: 4-(3H-inden-1-yl)cyclohexan-1-one
• CAS: 66248-90-6
• 化学式: C₁₅H₁₆O
• 分子量: 212.291
• InChiKey: JLKQRAXHDJBKDU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  16
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• BENZOFURANYL- AND BENZOTHIENYL- PIPERAZINYL QUINOLINES AND METHODS OF THEIR USE
  申请人：Venkatesan Aranapakam Mudumbai

  公开号：US20090054454A1

  公开（公告）日：2009-02-26

  Benzofuranyl- and benzothienyl-piperzinyl quinoline derivatives and compositions containing such compounds are disclosed. Methods of using benzofuranyl- and benzothienyl-piperzinyl quinoline derivatives and compositions containing such composition in the treatment and/or prevention of serotonin-related disorders, such as depression and anxiety, are also disclosed. In addition, processes for the preparation of benzofuranyl- and benzothienyl-piperzinyl quinoline derivatives are disclosed.

  本专利揭示了苯并呋喃基和苯并噻吩基哌嗪喹啉衍生物以及含有这些化合物的组合物。还揭示了使用苯并呋喃基和苯并噻吩基哌嗪喹啉衍生物以及含有这种组合物在治疗和/或预防与5-羟色胺相关的疾病，如抑郁症和焦虑症的方法。此外，还揭示了制备苯并呋喃基和苯并噻吩基哌嗪喹啉衍生物的方法。
• Benzofuranyl-and benzothienyl-piperazinyl quinolines and methods of their use
  申请人：Venkatesan Mudumbai Aranapakam

  公开号：US20050059673A1

  公开（公告）日：2005-03-17

  Benzofuranyl- and benzothienyl-piperzinyl quinoline derivatives and compositions containing such compounds are disclosed. Methods of using benzofuranyl- and benzothienyl-piperzinyl quinoline derivatives and compositions containing such composition in the treatment and/or prevention of serotonin-related disorders, such as depression and anxiety, are also disclosed. In addition, processes for the preparation of benzofuranyl- and benzothienyl-piperzinyl quinoline derivatives are disclosed.

  本发明涉及苯并呋喃基-和苯并噻吩基-哌嗪基喹啉衍生物及含有该类化合物的组合物。本发明还涉及使用苯并呋喃基-和苯并噻吩基-哌嗪基喹啉衍生物及含有该类组合物治疗和/或预防与血清素相关的疾病，例如抑郁和焦虑。此外，还公开了制备苯并呋喃基-和苯并噻吩基-哌嗪基喹啉衍生物的方法。
• BENZOFURANYL-AND BENZOTHIENYL-PIPERAZINYL QUINOLINES AS SEROTONIN REUPTAKE INHIBITORS
  申请人：Wyeth

  公开号：EP1641785A2

  公开（公告）日：2006-04-05
• US7276603B2
  申请人：——

  公开号：US7276603B2

  公开（公告）日：2007-10-02
• [EN] BENZOFURANYL-AND BENZOTHIENYL-PIPERAZINYL QUINOLINES AND METHODS OF THEIR USE<br/>[FR] QUINOLINES BENZOFURANYL ET BENZOTHIENYL-PIPERAZINYL ET LEURS PROCEDES D'UTILISATION
  申请人：WYETH CORP

  公开号：WO2004099191A2

  公开（公告）日：2004-11-18

  Benzofuranyl-and benzothienyl-piperzinyl quinoline derivatives and compositions containing such compounds are disclosed. Methods of using benzofuranyl- and benzothienyl-piperzinyl quinoline derivatives and compositions containing such composition in the treatment and/or prevention of serotonin-related disorders, such as depression and anxiety, are also disclosed. In addition, processes for the preparation of benzofuranyl- and benzothienyl-piperzinyl quinoline derivatives are disclosed.