57Hbp7xks9 | 1224953-72-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 57Hbp7xks9
• 英文别名: [2-[4-[[4-[benzyl(ethyl)amino]phenyl]diazenyl]anilino]-2-oxoethyl]-triethylazanium
• CAS: 1224953-72-3
• 化学式: C₂₉H₃₈N₅O
• 分子量: 472.654
• InChiKey: XJSTVCBWJAUVAR-UHFFFAOYSA-O

计算性质

• 辛醇/水分配系数(LogP)：
  6
• 重原子数：
  35
• 可旋转键数：
  12
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.34
• 拓扑面积：
  57.1
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  N-乙基-N-苄基苯胺 在 盐酸 、 sodium sulfide 、 水 、 N,N-二异丙基乙胺 、 亚硝酸异戊酯 作用下， 以 1,4-二氧六环 、 甲醇 、 N,N-二甲基甲酰胺 为溶剂， 生成 57Hbp7xks9
  参考文献：
  名称：

  Tuning Photochromic Ion Channel Blockers

  摘要：

  Photochromic channel blockers provide a conceptually simple and convenient way to modulate neuronal activity with light. We have recently described a family of azobenzenes that function as tonic blockers of K-v channels but require UV-A light to unblock and need to be actively switched by toggling between two different wavelengths. We now introduce red-shifted compounds that fully operate in the visible region of the spectrum and quickly turn themselves off in the dark. Furthermore, we have developed a version that does not block effectively in the dark-adapted state, can be switched to a blocking state with blue light, and reverts to the inactive state automatically. Photochromic blockers of this type could be useful for the photopharmacological control of neuronal activity under mild conditions.

  DOI：

  10.1021/cn200037p

文献信息

• PHOTOREACTIVE SYNTHETIC REGULATOR OF PROTEIN FUNCTION AND METHODS OF USE THEREOF
  申请人：The Regents of the University of California

  公开号：US20150158811A1

  公开（公告）日：2015-06-11

  The present disclosure provides a photoreactive synthetic regulator of protein function. The present disclosure further provides a light-regulated polypeptide that includes a subject synthetic regulator. Also provided are cells and membranes comprising a subject light-regulated polypeptide. The present disclosure further provides methods of modulating protein function, involving use of light.

  本公开提供了一种光反应合成蛋白功能调节剂。本公开还提供了一种包括所述合成调节剂的光调控多肽。还提供了包括所述光调控多肽的细胞和膜。本公开还提供了一种调节蛋白功能的方法，涉及使用光。
• Photoreactive Synthetic Regulator of Protein Function and Methods of Use Thereof
  申请人：Trauner Dirk

  公开号：US20110207213A1

  公开（公告）日：2011-08-25

  The present disclosure provides a photoreactive synthetic regulator of protein function. The present disclosure further provides a light-regulated polypeptide that includes a subject synthetic regulator. Also provided are cells and membranes comprising a subject light-regulated polypeptide. The present disclosure further provides methods of modulating protein function, involving use of light.

  本公开提供了一种光敏合成蛋白功能调节剂。本公开进一步提供了一种包含所述合成调节剂的光调控多肽。同时还提供了包含所述光调控多肽的细胞和膜。本公开进一步提供了利用光调节蛋白功能的方法。
• AFFINITY-TAGGED PHOTOSWITCHES AND METHODS OF USE THEREOF
  申请人：The Regents of the University of California

  公开号：US20200308539A1

  公开（公告）日：2020-10-01

  The present disclosure provides a conjugate comprising: a) an affinity agent that specifically binds a target ligand-binding polypeptide; and b) a photoisomerizable regulator comprising: i) a photoisomerizable moiety; and ii) a ligand that binds to the target ligand-binding polypeptide. The present disclosure provides cells comprising a conjugate of the present disclosure. The present disclosure provides methods of using a conjugate of the present disclosure to modulate activity of a target polypeptide, and to modulate activity of a target cell or cell population.
• US8993736B2
  申请人：——

  公开号：US8993736B2

  公开（公告）日：2015-03-31
• US9334231B2
  申请人：——

  公开号：US9334231B2

  公开（公告）日：2016-05-10