3-羟基-5-氧代己酸 | 109138-72-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羟基酸及其衍生物
• 中文名称: 3-羟基-5-氧代己酸
• 英文名称: 3-Hydroxy-5-oxohexanoic acid
• CAS: 109138-72-9
• 化学式: C₆H₁₀O₄
• 分子量: 146.14
• InChiKey: APWDZEIBFNZVND-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.2
• 重原子数：
  10
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  74.6
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• [EN] PROCESS AND INTERMEDIATES FOR THE SELECTIVE SYNTHESIS OF FLUVASTATIN<br/>[FR] PROCÉDÉ ET INTERMÉDIAIRES POUR LA SYNTHÈSE SÉLECTIVE DE LA FLUVASTATINE
  申请人：ZHEJIANG HISUN PHARMACEUTICAL

  公开号：WO2006021326A1

  公开（公告）日：2006-03-02

  The invention relates to process for the selective preparation of 3-hydroxy-6-dialkoxyphosphoryl-5-oxo-hexanoic acid esters, comprising a first step, in which a methylphosphonic acid dialkylester is treated with a base, and a second step, in which the product of the primary reaction is reacted with an optionally 3-protected 3-hydroxy-1,5-pentanoic diacid ester.

  这项发明涉及一种选择性制备3-羟基-6-二烷氧基磷酰基-5-氧代己酸酯的方法，包括第一步，在该步骤中，甲基膦酸二烷基酯与碱反应，以及第二步，在该步骤中，初级反应产物与可选的3-保护的3-羟基-1,5-戊二酸酯发生反应。
• MICROORGANISMS AND METHODS FOR THE BIOSYNTHESIS OF BUTADIENE
  申请人：Genomatica, Inc.

  公开号：US20140155567A1

  公开（公告）日：2014-06-05

  The invention provides non-naturally occurring microbial organisms having a butadiene pathway. The invention additionally provides methods of using such organisms to produce butadiene.

  该发明提供了具有丁二烯途径的非自然微生物生物体。此外，该发明还提供了利用这些生物体生产丁二烯的方法。
• $g(a), $g(a)-TREHALOSE TRIMYCOLATE AND MEDICINAL COMPOSITION
  申请人：SAWAI PHARMACEUTICAL CO., LTD.

  公开号：EP0261248A1

  公开（公告）日：1988-03-30

  a,a-Trehalose trimycolates represented by formula (I), wherein R' to RB each represents a hydrogen atom or a mycolic acid residue, with three of R1 to R8 being the mycolic acid residues, provided that the mycolic acid residues may be the same or different from each other. The a,a-trehalose trimycolates have immuno-activating and oncostatic activities on animals with low toxicity, and hence they are expected to be used for preventing infection by various microorganisms or as an oncostatic agent and for activating immunity upon the decline of bodily strength.

  由式（I）代表的 a,a-三羟甲基氨基甲烷，其中 R' 至 RB 分别代表氢原子或霉菌酸残基，R1 至 R8 中的三个为霉菌酸残基，但霉菌酸残基可以相同或不同。 a,a-三羟甲基氨基甲烷对动物具有免疫激活和抗成本活性，且毒性低，因此有望用于预防各种微生物感染或作为抗成本剂，以及在体力下降时激活免疫力。
• Process and intermediates for the selective synthesis of Fluvastatin
  申请人：Zhejiang Hisun Pharmaceutical Co. Ltd.

  公开号：EP1634870A1

  公开（公告）日：2006-03-15

  The invention relates to process for the selective preparation of 3-hydroxy-6-dialkoxyphosphoryl-5-oxo-hexanoic acid esters, comprising a first step, in which a methylphosphonic acid dialkylester is treated with a base, and a second step, in which the product of the primary reaction is reacted with an optionally 3-protected 3-hydroxy-1,5-pentanoic diacid ester.

  本发明涉及选择性制备 3-hydroxy-6-dialkoxyphosphoryl-5-oxo-hexanoic acid esters 的工艺，包括第一步，用碱处理甲基膦酸二烷基酯，以及第二步，将主反应产物与选择性 3 保护的 3-hydroxy-1,5-pentanoic diacid ester 反应。
• Microorganisms for producing butadiene and methods related thereto
  申请人：Genomatica, Inc.

  公开号：US10006055B2

  公开（公告）日：2018-06-26

  The invention provides non-naturally occurring microbial organisms having a butadiene or crotyl alcohol pathway. The invention additionally provides methods of using such organisms to produce butadiene or crotyl alcohol.

  本发明提供了具有丁二烯或巴豆醇途径的非天然微生物。此外，本发明还提供了利用此类生物生产丁二烯或巴豆醇的方法。