keto/aldehyde acetals (X = OMe) followed by the addition of a Lewis acid leads to five-, six-, and seven-membered hydroxycycloalkene carboxyates. The utility of this method is demonstrated in the synthesis of the α-alkylidene lactone natural products subamolide D and E.
用醛和/或酮(2和4)和BF 3 ·OEt 2顺序处理(
乙氧基乙炔基)
锂可产生β-羟基烯酸酯5,总收率良好。类似地,1(M = Li)和二羰基化合物6(X = O)或酮/醛
缩醛(X = OMe)的组合,然后添加
路易斯酸,会生成五元,六元和七元羟基环烯
羧酸盐。该方法的实用性在合成α-亚烷基内酯
天然产物亚磺酰胺D和E中得到了证明。