3-羟基-8-甲基癸酸 | 62675-80-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羟基酸及其衍生物
• 中文名称: 3-羟基-8-甲基癸酸
• 英文名称: 3-Hydroxy-8-methyldecanoic acid
• CAS: 62675-80-3
• 化学式: C₁₁H₂₂O₃
• 分子量: 202.29
• InChiKey: WRODZWONXSGQFZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  14
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.91
• 拓扑面积：
  57.5
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• Endotoxin assay
  申请人：NATIONAL RESEARCH DEVELOPMENT CORPORATION

  公开号：EP0265127A1

  公开（公告）日：1988-04-27

  It has been a problem that the known LAL method of endotoxin assay suffers from batch-to-batch differences in sensitivity, does not measure absolute amounts of endotoxin and gives some false positives. The assay of the invention quantitates endotoxin by making use of the binding interaction of the lipopolysaccharide (LPS) component of endotoxin with a polymyxin or octapeptin or a similar cyclic peptide. The cyclic peptide or the LPS is labelled, preferably enzyme-labelled.

  已知的 LAL 内毒素测定法存在一个问题，即批次与批次之间的灵敏度存在差异，不能测定内毒素的绝对量，而且会出现一些假阳性。 本发明的测定法利用内毒素中的脂多糖（LPS）成分与多粘菌素或八肽或类似的环肽的结合作用来定量测定内毒素。 环肽或 LPS 已被标记，最好是酶标记。
• Peptide antibiotics
  申请人：THE UNIVERSITY OF QUEENSLAND

  公开号：US11279733B2

  公开（公告）日：2022-03-22

  There is provided a range of novel compounds. These novel compounds may demonstrate abroad spectrum antibacterial and antifungal activity. These compounds may be active against the emerging polymyxin resistant bacteria. These compounds may also be useful when used in conjunction with other pharmaceutically active agents.

  本文提供了一系列新型化合物。这些新型化合物可显示出国外光谱的抗菌和抗真菌活性。这些化合物对新出现的多粘菌素耐药菌具有活性。这些化合物与其他药物活性剂一起使用时也可能很有用。
• PEPTIDE ANTIBIOTICS
  申请人：THE UNIVERSITY OF QUEENSLAND

  公开号：US20200361994A1

  公开（公告）日：2020-11-19

  There is provided a range of novel compounds. These novel compounds may demonstrate abroad spectrum antibacterial and antifungal activity. These compounds may be active against the emerging polymyxin resistant bacteria. These compounds may also be useful when used in conjunction with other pharmaceutically active agents.
• US4341768A
  申请人：——

  公开号：US4341768A

  公开（公告）日：1982-07-27
• US4360593A
  申请人：——

  公开号：US4360593A

  公开（公告）日：1982-11-23