申请人:Hanson Gunnar J.
公开号:US20120082640A1
公开(公告)日:2012-04-05
The invention provides small molecule mimics of the Smac peptide that are dimer- or dimer-like compounds having two amide-containing domains connected by a linker. These compounds are useful to promote apoptosis. The invention includes pharmaceutical compositions comprising such compounds and methods to use them to treat conditions including cancer and autoimmune disorders.
该发明提供了Smac肽的小分子模拟物,它们是由两个含有酰胺的结构域通过连接器连接而成的二聚体或类似二聚体化合物。这些化合物有助于促进细胞凋亡。发明还包括包含这些化合物的制药组合物以及使用它们治疗癌症和自身免疫性疾病等疾病的方法。