3-(2-Benzylamino-propyl)-indol | 4822-04-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 3-(2-Benzylamino-propyl)-indol
• 英文别名: benzyl-(2-indol-3-yl-1-methyl-ethyl)-amine；N-benzyl-1-(1H-indol-3-yl)propan-2-amine
• CAS: 4822-04-2
• 化学式: C₁₈H₂₀N₂
• 分子量: 264.37
• InChiKey: QRYFNEVDHFVBLZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  20
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  27.8
• 氢给体数：
  2
• 氢受体数：
  1

文献信息

• [EN] METHODS OF TREATING ESTROGEN RECEPTOR-ASSOCIATED DISEASES<br/>[FR] MÉTHODES DE TRAITEMENT DE MALADIES ASSOCIÉES AU RÉCEPTEUR DES ŒSTROGÈNES
  申请人：OLEMA PHARMACEUTICALS INC

  公开号：WO2021178846A1

  公开（公告）日：2021-09-10

  The present disclosure provides methods of treating estrogen receptor-associated diseases, disorders, and conditions.

  本公开提供了治疗雌激素受体相关疾病、疾病和症状的方法。
• [EN] REGIMENS OF ESTROGEN RECEPTOR ANTAGONISTS<br/>[FR] RÉGIMES D'ANTAGONISTES DU RÉCEPTEUR DES OESTROGÈNES
  申请人：OLEMA PHARMACEUTICALS INC

  公开号：WO2021007146A1

  公开（公告）日：2021-01-14

  Provided herein are methods of administering estrogen receptor antagonists for use in treatment of cancer. The antagonists (such as a hexahydro pyrido[3,4-b]indole, AZD9496, RAD-1901, ARN-810, endoxifen, or fulvestrant) may be an inhibitor of both activating function 1 and activating function 2 of the estrogen receptor. Also provided are combinations of above inhibitors with a secondary agent, which is a CDK 4/6 inhibitor (such as, palbocociclib, ribociclib, abemaciclib, lerociclib, and trilaciclib).

  本文提供了一种用于治疗癌症的雌激素受体拮抗剂的给药方法。这些拮抗剂（如六氢吡啶并[3,4-b]吲哚、AZD9496、RAD-1901、ARN-810、内多西芬或富维司汀）可能是雌激素受体的激活功能1和激活功能2的抑制剂。还提供了上述抑制剂与次级药物的组合，该次级药物是CDK 4/6抑制剂（如帕博可西尼、利博西尼、阿贝马西尼、勒罗西尼和特利西尼）。
• [EN] CONTINUOUS FLOW PROCESSES FOR MAKING BICYCLIC COMPOUNDS<br/>[FR] PROCÉDÉS À FLUX CONTINU POUR LA FABRICATION DE COMPOSÉS BICYCLIQUES
  申请人：ZENO ROYALTIES & MILESTONES LLC

  公开号：WO2019051038A1

  公开（公告）日：2019-03-14

  Processes for making bicyclic compounds and precursors thereof, and particularly for making [1.1.1]propellane and bicyclo[1.1.1]pentane and derivatives thereof, utilize continuous flow reaction methods and conditions. A continuous process for making [1.1.1]propellane can be conducted under reaction conditions that advantageously minimize clogging of a continuous flow reactor. A continuous flow process can be used to make precursors of [1.1.1]propellane.

  制备双环化合物及其前体物的过程，尤其是制备[1.1.1]丙烷和双环[1.1.1]戊烷及其衍生物的过程，采用连续流反应方法和条件。可以在有利于最小化连续流反应器堵塞的反应条件下进行制备[1.1.1]丙烷的连续过程。连续流程可用于制备[1.1.1]丙烷的前体物。
• Continuous flow processes for making bicyclic compounds
  申请人：Recurium IP Holdings, LLC

  公开号：US11339103B2

  公开（公告）日：2022-05-24

  Processes for making bicyclic compounds and precursors thereof, and particularly for making [1.1.1]propellane and bicyclo[1.1.1]pentane and derivatives thereof, utilize continuous flow reaction methods and conditions. A continuous process for making [1.1.1]propellane can be conducted under reaction conditions that advantageously minimize clogging of a continuous flow reactor. A continuous flow process can be used to make precursors of [1.1.1]propellane.

  制造双环化合物及其前体的工艺，特别是制造[1.1.1]丙烷和双环[1.1.1]戊烷及其衍生物的工艺，采用连续流反应方法和条件。制造[1.1.1]丙烷的连续工艺可以在反应条件下进行，这样可以最大限度地减少连续流反应器的堵塞。连续流工艺可用于制造[1.1.1]丙烷的前体。
• TETRAHYDRO-1H-PYRIDO[3,4-b]INDOLE ANTI-ESTROGENIC DRUGS
  申请人：Olema Pharmaceuticals, Inc.

  公开号：EP3355884B1

  公开（公告）日：2021-04-28