3-bromo-7-hydrazino-5-p-methylphenyl-2-phenylpyrazolo[1,5-c]pyrimidine | 1338219-44-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 3-bromo-7-hydrazino-5-p-methylphenyl-2-phenylpyrazolo[1,5-c]pyrimidine
• CAS: 1338219-44-5
• 化学式: C₁₉H₁₆BrN₅
• 分子量: 394.274
• InChiKey: PWBOFOVWLAGIJS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.42
• 重原子数：
  25.0
• 可旋转键数：
  3.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  68.24
• 氢给体数：
  2.0
• 氢受体数：
  5.0

反应信息

• 作为反应物：
  描述：

  二硫化碳 、 3-bromo-7-hydrazino-5-p-methylphenyl-2-phenylpyrazolo[1,5-c]pyrimidine 在 potassium hydroxide 作用下， 以 乙醇 、 水 为溶剂， 反应 3.0h， 以72.73%的产率得到7-bromo-5-p-methylphenyl-8-phenyl-2H-pyrazolo[1,5-c]-1,2,4-triazolo[4,3-a]pyrimidine-3-thione
  参考文献：
  名称：

  Annulation and Evaluation of Antibacterial Activity of the New Fused Tricyclic (5,5,6) Ring System of Pyrazolo[1,5-c]-1,2,4-triazolo[4,3-a]pyrimidines

  摘要：

  A series of the new fused 5-aryl-8-phenyl-2H-pyrazolo[1,5-c]-1,2,4-triazolo[4,3-a]pyrimidine-3-thiones 2 were prepared in excellent yields by the reaction of 5-aryl-7-hydrazino-2-phenylpyrazolo[1,5-c]pyrimidines 1 with carbon disulfide in the presence of potassium hydroxide. The pyrazolotriazolopyrimidinethiones gave with certain electrophiles the respective 6-substituted 3-thiones 4-6 rather than the 7-substituted isomeric structure 7. Oxidation of 2 with sodium nitrite or benzenediazonuim chloride afforded the corresponding disulfides 9 or 10 respectively. Moreover, the pyrazolotriazolopyrimidinones 8 were prepared upon reaction with alkaline hydrogen peroxide. All the above compounds were evaluated as antibacterial agents against a variety of microorganisms.

  DOI：

  10.3987/com-11-12240
• 作为产物：
  描述：

  3-bromo-5-p-methylphenyl-2-phenyl-6H-pyrazolo[1,5-c]pyrimidine-7-thione 在 一水合肼 作用下， 以 乙醇 为溶剂， 反应 20.0h， 以80%的产率得到3-bromo-7-hydrazino-5-p-methylphenyl-2-phenylpyrazolo[1,5-c]pyrimidine
  参考文献：
  名称：

  Annulation and Evaluation of Antibacterial Activity of the New Fused Tricyclic (5,5,6) Ring System of Pyrazolo[1,5-c]-1,2,4-triazolo[4,3-a]pyrimidines

  摘要：

  A series of the new fused 5-aryl-8-phenyl-2H-pyrazolo[1,5-c]-1,2,4-triazolo[4,3-a]pyrimidine-3-thiones 2 were prepared in excellent yields by the reaction of 5-aryl-7-hydrazino-2-phenylpyrazolo[1,5-c]pyrimidines 1 with carbon disulfide in the presence of potassium hydroxide. The pyrazolotriazolopyrimidinethiones gave with certain electrophiles the respective 6-substituted 3-thiones 4-6 rather than the 7-substituted isomeric structure 7. Oxidation of 2 with sodium nitrite or benzenediazonuim chloride afforded the corresponding disulfides 9 or 10 respectively. Moreover, the pyrazolotriazolopyrimidinones 8 were prepared upon reaction with alkaline hydrogen peroxide. All the above compounds were evaluated as antibacterial agents against a variety of microorganisms.

  DOI：

  10.3987/com-11-12240