phosphonic acid bis-ethoxycarbonylmethyl ester | 93223-66-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: phosphonic acid bis-ethoxycarbonylmethyl ester
• 英文别名: 4-Oxo-3,5-dioxa-4λ⁵-phospha-heptandisaeure-diaethylester；Phosphonsaeure-bis-aethoxycarbonylmethylester
• CAS: 93223-66-6
• 化学式: C₈H₁₅O₇P
• 分子量: 254.177
• InChiKey: QXMDGBDELARZHR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.54
• 重原子数：
  16.0
• 可旋转键数：
  8.0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  88.13
• 氢给体数：
  0.0
• 氢受体数：
  7.0

反应信息

• 作为反应物：
  描述：

  phosphonic acid bis-ethoxycarbonylmethyl ester 在 氯 作用下， 生成 chlorophosphoric acid bis-ethoxycarbonylmethyl ester
  参考文献：
  名称：

  Rasumow; Korobkowa, Metodiceskij sbornik, 1957, # 23, p. 215

  摘要：

  DOI：
• 作为产物：
  描述：

  乙醇酸乙酯 在 三氯化磷 作用下， 生成 phosphonic acid bis-ethoxycarbonylmethyl ester
  参考文献：
  名称：

  Gerrard et al., Journal of the Chemical Society, 1953, p. 1920,1922

  摘要：

  DOI：

文献信息

• [EN] NOVEL E,E-DIENE COMPOUNDS AND THEIR USE AS MEDICAMENTS AND COSMETICS<br/>[FR] NOUVEAUX COMPOSÉS E,E-DIÉNIQUES ET LEUR UTILISATION COMME MÉDICAMENTS ET PRODUITS COSMÉTIQUES
  申请人：WOLFF AUGUST GMBH & CO KG ARZNEIMITTEL DR

  公开号：WO2012069605A1

  公开（公告）日：2012-05-31

  The present invention relates to a novel class of E,E-diene compounds and their use as a medicament, preferably as a dermatologic agent, and as a cosmetic. These novel compounds are particularly useful in treating and/or preventing inflammation, irritation, itching, pruritus, pain, oedema and/or pro-allergic or allergic conditions in a patient. Usually they are topically applied to the skin or mucosa in the form of a pharmaceutical or cosmetic composition comprising the compound and a pharmaceutically and/or cosmetically acceptable carrier.

  本发明涉及一种新型的E,E-二烯化合物及其作为药物的用途，优选作为皮肤科药剂和化妆品。这些新型化合物在治疗和/或预防病人的炎症、刺激、瘙痒、瘙痒、疼痛、水肿和/或过敏或过敏性疾病方面特别有用。通常它们以药用或化妆品组合物的形式局部应用于皮肤或粘膜，该组合物包括该化合物和药学和/或化妆学上可接受的载体。
• [EN] COMPOSITIONS AND METHODS FOR ASCAROSIDE MODIFICATION OF MAMMALIAN MICROBIOTA<br/>[FR] COMPOSITIONS ET MÉTHODES D'ADMINISTRATION DE MICROBIOTE DE MAMMIFÈRE
  申请人：HOLOCLARA INC

  公开号：WO2020247480A1

  公开（公告）日：2020-12-10

  Described herein are composition of ascarosides, methods of using them, and the like for inhibiting bacterial population growth or for altering the relative ratio of sub-populations of first and second bacteria in a mixed population of bacteria. The invention is particularly useful, for example, for modifying a microbiome of a patient (e.g., for treatment of gut microbiome dysfunction).

  本文描述了ascarosides的组成，它们的使用方法等，用于抑制细菌种群生长或改变混合细菌种群中第一和第二细菌亚种的相对比例等。该发明特别有用，例如，用于修改患者的微生物组（例如，用于治疗肠道微生物组功能障碍）。
• [EN] ASCAROSIDE DERIVATIVES AND METHODS OF USE<br/>[FR] DÉRIVÉS D'ASCAROSIDE ET PROCÉDÉS D'UTILISATION
  申请人：CALIFORNIA INST OF TECHN

  公开号：WO2020236621A1

  公开（公告）日：2020-11-26

  The present invention relates to methods of treating immune disorders and/or inflammation using certain modulator compounds. For example, the present invention provides methods of treating immune and/or inflammatory disorders by administering a composition comprising a compound having the structure of Formula (I).

  本发明涉及使用特定调节剂化合物治疗免疫紊乱和/或炎症的方法。例如，本发明提供了通过给予含有具有Formula (I)结构的化合物的组合物来治疗免疫和/或炎症性疾病的方法。
• [EN] NOVEL 1,3-BENZOXAZOL-2(3H)-ONES AND THEIR USE AS MEDICAMENTS AND COSMETICS<br/>[FR] NOUVELLES 1,3-BENZOXAZOL-2(3H)-ONES ET LEUR UTILISATION COMME MÉDICAMENTS ET PRODUITS COSMÉTIQUES
  申请人：WOLFF AUGUST GMBH & CO KG ARZNEIMITTEL DR

  公开号：WO2013174508A1

  公开（公告）日：2013-11-28

  The present invention relates to a novel class of 1,3-benzoxazol-2(3H) -ones of formula (1) and their use as a medicament, preferably as a dermatologic agent, and as a cosmetic. These novel compounds are particularly useful in treating and/or preventing inflammation, irritation, itching, pruritus, pain, oedema and/or pro-allergic or allergic conditions in a patient. Usually they are topically applied to the skin or mucosa in the form of a pharmaceutical or cosmetic composition comprising the compound and a pharmaceutically and/or cosmetically acceptable carrier.

  本发明涉及一种新型的1,3-苯并噁唑-2(3H)-酮类化合物，其化学式为(1)，以及其作为药物的用途，优选作为皮肤科药剂和化妆品。这些新型化合物在治疗和/或预防患者的炎症、刺激、瘙痒、瘙痒、疼痛、水肿和/或过敏或过敏症状方面特别有用。通常它们以含有该化合物和药学和/或化妆上可接受的载体的药学或化妆品组合物的形式局部应用于皮肤或黏膜。
• SUBSTITUTED PIPERIDINO PHENYLOXAZOLIDINONES HAVING ANTIMICROBIAL ACTIVITY WITH IMPROVED IN VIVO EFFICACY
  申请人：Deshpande Prasad Keshav

  公开号：US20100144735A1

  公开（公告）日：2010-06-10

  The present invention provides agents having antimicrobial activity for preventing and treating infectious diseases. Thus, the present invention provides novel substituted piperidino phenyloxazolidinone derivatives, processes for making compounds as well as antimicrobial compositions containing said derivatives as active ingredients and methods of treating bacterial infections with the said derivatives.

  本发明提供具有抗微生物活性的药剂，用于预防和治疗传染病。因此，本发明提供了新型的取代的哌啶基苯并噁唑啉衍生物，制备该化合物的方法以及含有该衍生物作为活性成分的抗微生物组合物和使用该衍生物治疗细菌感染的方法。