(2S)-2-[[(Z)-dodec-5-enoyl]amino]pentanedioic acid | 1116632-52-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (2S)-2-[[(Z)-dodec-5-enoyl]amino]pentanedioic acid
• CAS: 1116632-52-0
• 化学式: C₁₇H₂₉NO₅
• 分子量: 327.421
• InChiKey: DYTQEOXVKGMDAD-DANTVBBOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  23
• 可旋转键数：
  14
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  104
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  在 lithium hydroxide 作用下， 以 四氢呋喃 、 水 为溶剂， 反应 2.0h， 生成 (2S)-2-[[(Z)-dodec-5-enoyl]amino]pentanedioic acid
  参考文献：
  名称：

  Synthesis and Evaluation of New Alkylamides Derived from α-Hydroxysanshool, the Pungent Molecule in Szechuan Pepper

  摘要：

  Szechuan pepper is widely used in Asia as a spice for its pleasant pungent and tingling sensations, produced by natural alkylamides called sanshools. alpha-Hydroxysanshool, the main alkylamide found in the pericarp of the fruit, stimulates sensory neurons innervating the mouth by targeting two chemosensitive members of the transient receptor potential (TRP) channels, TRPV1 and TRPA1. As it was previously found that configuration of the unsaturations in the alpha-hydroxysanshool alkyl chain is required for TRPA1 but not TRPV1 selectivity, this study aimed at obtaining more potent and selective TRPA1 agonists using alpha-hydroxysanshool as a starting material. This paper reports the preparation of new alkylamides derived from sanshool and their efficacy in stimulating TRPA1 and TRPV1 receptors. The data provide knowledge of the main sanshool chemical functionalities required for TRIP channel activation, but they also evidence new selective and potent TRPA1 agonists based on alpha-hydroxysanshool.

  DOI：

  10.1021/jf803067r

文献信息

• Surfactant and Composition
  申请人：AJINOMOTO CO., INC.

  公开号：US20220226217A1

  公开（公告）日：2022-07-21

  The present invention provides a surfactant that has good foaming, foam quality, and solubility even having a pH equivalent to that of the skin, which is weakly acidic, has a low viscosity with high handleability, and can be useful in a product such as a personal care product, for example, a cosmetic. More specifically, the present invention provides a surfactant including an N-monounsaturated acyl acidic amino acid or a salt thereof, wherein the N-monounsaturated acyl is an acyl having 10 to 16 carbon atoms.