1-[(2R,4S,5R)-4-[tert-butyl(diphenyl)silyl]oxy-5-[[(2R,3S,5R)-2-[[tert-butyl(diphenyl)silyl]oxymethyl]-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-3-yl]oxyphosphonoyloxymethyl]oxolan-2-yl]-5-methylpyrimidine-2,4-dione | 195968-51-5

• 分子结构分类: 有机化合物 - 有机杂环化合物
• 英文名称: 1-[(2R,4S,5R)-4-[tert-butyl(diphenyl)silyl]oxy-5-[[(2R,3S,5R)-2-[[tert-butyl(diphenyl)silyl]oxymethyl]-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-3-yl]oxyphosphonoyloxymethyl]oxolan-2-yl]-5-methylpyrimidine-2,4-dione
• CAS: 195968-51-5
• 化学式: C₅₂H₆₃N₄O₁₁PSi₂
• 分子量: 1007.24
• InChiKey: KKPQGQQTJPDKPF-ZOVUOCBOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.59
• 重原子数：
  70
• 可旋转键数：
  18
• 环数：
  8.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  171
• 氢给体数：
  2
• 氢受体数：
  11

反应信息

• 作为反应物：
  描述：

  1-[(2R,4S,5R)-4-[tert-butyl(diphenyl)silyl]oxy-5-[[(2R,3S,5R)-2-[[tert-butyl(diphenyl)silyl]oxymethyl]-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-3-yl]oxyphosphonoyloxymethyl]oxolan-2-yl]-5-methylpyrimidine-2,4-dione 在 四氮唑 、 4-二甲氨基吡啶 、 triethylamine trihydrofluoride 、 三乙胺 、 三氟乙酸 作用下， 以 吡啶 、 二氯甲烷 、 乙腈 为溶剂， 反应 35.5h， 生成
  参考文献：
  名称：

  Fpmp-Protected α-Hydroxyphosphonate Diesters for The Synthesis of Pro-Oligonucleotides

  摘要：

  The synthesis of Fpmp-protected alpha-hydroxybenzylphosphonate diesters as building blocks for the oligonucleotide synthesis is described. The modified oligonucleotides obtained after cleavage from the solid support and deprotection of the acid-labile Fpmp group should lead to potential pro-oligonucleotides.

  DOI：

  10.1080/07328319708002933
• 作为产物：
  描述：

  保护胸苷 在 吡啶 、 三甲基乙酰氯 、 苯甲酸 作用下， 反应 0.13h， 生成 1-[(2R,4S,5R)-4-[tert-butyl(diphenyl)silyl]oxy-5-[[(2R,3S,5R)-2-[[tert-butyl(diphenyl)silyl]oxymethyl]-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-3-yl]oxyphosphonoyloxymethyl]oxolan-2-yl]-5-methylpyrimidine-2,4-dione
  参考文献：
  名称：

  Fpmp-Protected α-Hydroxyphosphonate Diesters for The Synthesis of Pro-Oligonucleotides

  摘要：

  The synthesis of Fpmp-protected alpha-hydroxybenzylphosphonate diesters as building blocks for the oligonucleotide synthesis is described. The modified oligonucleotides obtained after cleavage from the solid support and deprotection of the acid-labile Fpmp group should lead to potential pro-oligonucleotides.

  DOI：

  10.1080/07328319708002933