(3R,3aR,4R,10cR)-tert-butyl 4-(4-chlorobenzoyl)-3-(4-chlorophenyl)-3-hydroxy-9-methoxy-2-oxo-1,3,3a,4,5,10c-hexahydrocyclopenta[c]carbazole-6(2H)- | 1360110-89-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: (3R,3aR,4R,10cR)-tert-butyl 4-(4-chlorobenzoyl)-3-(4-chlorophenyl)-3-hydroxy-9-methoxy-2-oxo-1,3,3a,4,5,10c-hexahydrocyclopenta[c]carbazole-6(2H)-
• CAS: 1360110-89-9
• 化学式: C₃₄H₃₁Cl₂NO₆
• 分子量: 620.529
• InChiKey: IBWWAQWPMGELLX-NUVICIQJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.36
• 重原子数：
  43.0
• 可旋转键数：
  4.0
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  94.83
• 氢给体数：
  1.0
• 氢受体数：
  7.0

反应信息

• 作为产物：
  描述：

  在 2-pentafluorophenyl-6,7-dihydro-5H-pyrrolo[2,1-c][1,2,4]triazol-2-ium tetrafluoroborate 、 sodium acetate 作用下， 以 甲苯 为溶剂， 反应 40.0h， 以40%的产率得到(3R,3aR,4R,10cR)-tert-butyl 4-(4-chlorobenzoyl)-3-(4-chlorophenyl)-3-hydroxy-9-methoxy-2-oxo-1,3,3a,4,5,10c-hexahydrocyclopenta[c]carbazole-6(2H)-
  参考文献：
  名称：

  Multicatalytic Asymmetric Synthesis of Complex Tetrahydrocarbazoles via a Diels–Alder/Benzoin Reaction Sequence

  摘要：

  Expanding upon the recently developed aminocatalytic asymmetric indole-2,3-quinodimethane strategy, a straightforward synthesis of structurally and stereochemically complex tetrahydrocarbazoles has been devised. The chemistry's complexity-generating power was further harnessed by designing a multicatalytic, one-pot Diels-Alder/benzoin reaction sequence to stereoselectively access trans-fused tetracyclic indole-based compounds having four stereogenic centers with very high fidelity.

  DOI：

  10.1021/ol300192p