Ethyl 5-heptyloxy-3-[2-(1H-imidazol-1-yl)ethyl]-1-indolinepropionate oxalate | 132482-88-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯二氮卓类
• 英文名称: Ethyl 5-heptyloxy-3-[2-(1H-imidazol-1-yl)ethyl]-1-indolinepropionate oxalate
• 英文别名: Ethyl 3-[5-heptoxy-3-(2-imidazol-1-ylethyl)-2,3-dihydroindol-1-yl]propanoate;oxalic acid
• CAS: 132482-88-3
• 化学式: C₂H₂O₄*C₂₅H₃₇N₃O₃
• 分子量: 517.623
• InChiKey: IUOBUNKNRCNAKE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.34
• 重原子数：
  37
• 可旋转键数：
  16
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  131
• 氢给体数：
  2
• 氢受体数：
  9

文献信息

• NEW IMIDAZOLE DERIVATIVES, PRODUCTION THEREOF, AND USES THEREOF AS MEDICINES
  申请人：Kyoto Pharmaceutical Industries, Ltd.

  公开号：EP0427860A1

  公开（公告）日：1991-05-22

  Imidazole derivatives of general formula (I) and pharmacologically acceptable salts thereof, wherein m and n are each an integer of 1 to 3, R' is hydrogen or ester residue, and the indoline skeleton may be substituted by at least one member selected from a C, to C10 alkyl group and a C1 to C15 alkoxy group. These compounds have excellent pharmacological actions such as inhibition of lipid peroxide formation, inhibition of platelet agglutination caused by thromboxane A2 synthetase inhibition, and vasodilation. Thus they are effectively used in preventing or treating asthma, thrombosis, embolism, arteriosclerosis, hypertension, hyperlipemia, cerebral apoplexy, cardiac infarction, dementia, diabetes, etc.

  咪唑衍生物及其药学上可接受的盐，通式(I)，其中m和n均为1至3的整数，R'为氢或酯基，吲哚啉骨架可被至少一个选自C1至C10烷基组和C1至C15烷氧基组的成员取代。这些化合物具有优异的药理作用，如抑制脂质过氧化形成、抑制由血栓素A2合成酶抑制引起的血小板凝集以及血管扩张。因此，它们有效地用于预防或治疗哮喘、血栓形成、栓塞、动脉硬化、高血压、高脂血症、脑卒中、心肌梗死、痴呆、糖尿病等。