5-(2-chlorobenzyl)-2-hydroxy-3-nitrobenzaldehyde | 292644-32-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 5-(2-chlorobenzyl)-2-hydroxy-3-nitrobenzaldehyde
• 英文别名: 5-(2-chlorobenzyl)-3-nitrosalicylaldehyde；5-[(2-chlorophenyl)methyl]-2-hydroxy-3-nitrobenzaldehyde
• CAS: 292644-32-7
• 化学式: C₁₄H₁₀ClNO₄
• mdl: MFCD02063067
• 分子量: 291.691
• InChiKey: WWNPAYUIEZTOAI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  83.1
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  5-溴水杨醛 在 2-双环己基膦-2',6'-二甲氧基联苯 、 硝酸铵 、 三氟乙酸酐 作用下， 以 四氢呋喃 、 氯仿 为溶剂， 反应 6.0h， 生成 5-(2-chlorobenzyl)-2-hydroxy-3-nitrobenzaldehyde
  参考文献：
  名称：

  Structure–Activity Relationship Study on Col-003, a Protein–Protein Interaction Inhibitor between Collagen and Hsp47

  摘要：

  本研究证明了 Col-003 这种强效胶原-热休克蛋白 47（Hsp47）相互作用抑制剂的结构-活性关系。通过钯（0）催化的 5-溴水杨醛衍生物与烷基金属的交叉偶联反应，成功合成了 Col-003 类似物，并利用表面等离子共振分析（BIAcore）评估了合成类似物的抑制活性。我们成功地发现了两种强效抑制剂，在 1.9 µM 的浓度下，它们对胶原蛋白-Hsp47 相互作用的抑制率分别为 85% 和 81%。这表明，在两个芳香环之间拉长烷基连接物可以大大提高抑制活性，这是因为除了与烷基连接物的疏水相互作用外，还可以将悬挂的苯基调整到适当的位置。

  DOI：

  10.1248/cpb.c19-00634

文献信息

• Bacterial influence on regulation of appetite via ClpB protein mimicry of alpha-MSH
  申请人：Institut National de la Sante et de la Recherche Medicale (INSERM)

  公开号：US10729770B2

  公开（公告）日：2020-08-04

  The present invention relates to ClpB expressing bacteria and their impact on obesity. The present invention relates to bacterial ClpB protein and ClpB expressing bacteria and their impact on eating disorders. The invention further relates to compositions comprising antibiotic directed against at least one ClpB expressing bacterium as well as probiotics not expressing ClpB protein and their use in the treatment or prevention of eating disorders. The invention also relates to diagnostic tools for determining whether a subject is likely to respond to a method of treating eating disorders and to methods of immunization against eating disorders.

  本发明涉及 ClpB 表达细菌及其对肥胖症的影响。本发明涉及细菌 ClpB 蛋白和 ClpB 表达细菌及其对饮食失调的影响。本发明还涉及包含针对至少一种 ClpB 表达细菌的抗生素的组合物以及不表达 ClpB 蛋白的益生菌及其在治疗或预防进食障碍中的用途。本发明还涉及用于确定受试者是否可能对治疗饮食失调症的方法产生反应的诊断工具，以及针对饮食失调症的免疫方法。
• BACTERIAL INFLUENCE ON REGULATION OF APPETITE VIA CLPB PROTEIN MIMICRY OF ALPHA-MSH
  申请人：Institut National de la Santé et de la Recherche Médicale

  公开号：EP3076985A1

  公开（公告）日：2016-10-12
• BACTERIAL INFLUENCE OF HOST FEEDING AND EMOTION VIA CLPB PROTEIN MIMICRY OF A-MSH
  申请人：Institut National de la Santé et de la Recherche Médicale

  公开号：EP3076986A1

  公开（公告）日：2016-10-12
• [EN] BACTERIAL INFLUENCE ON REGULATION OF APPETITE VIA CLPB PROTEIN MIMICRY OF ALPHA-MSH<br/>[FR] INFLUENCE BACTERIENNE SUR LA REGULATION DE L'APPETIT PAR MIMETISME ENTRE LA PROTEINE CLP B ET L'ALPHA MSH
  申请人：INST NAT SANTE RECH MED

  公开号：WO2015082633A1

  公开（公告）日：2015-06-11

  The present invention relates to bacterial Clp B protein and Clp B expressing bacteria and their impact on eating disorders. The invention further relates to compositions comprising antibiotic directed against at least one Clp B expressing bacterium as well as probiotics not expressing Clp B protein and their use in the treatment or prevention of eating disorders. The invention also relates to diagnostic tools for determining whether a subject is likely to respond to a method of treating eating disorders and to methods of immunization against eating disorders.
• [EN] BACTERIAL INFLUENCE OF HOST FEEDING AND EMOTION VIA CLPB PROTEIN MIMICRY OF A-MSH<br/>[FR] INFLUENCE BACTÉRIENNE SUR LES ÉMOTIONS ET L'ALIMENTATION D'UN HÔTE VIA L'A-MSH MIMÉTIQUE DE LA PROTÉINE CLPB
  申请人：INST NAT SANTE RECH MED

  公开号：WO2015082655A1

  公开（公告）日：2015-06-11

  The present invention relates to bacterial Clp B protein and Clp B expressing bacteria and their impact on diseases or disorders related to reduced appetite, increased appetite and/or anxiety. The invention further relates to compositions related to bacterial ClpB protein and to its use in the immunization against a disorder related to reduced appetite and/or anxiety.