Radicicol A | 160191-26-4

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 大环内酯类和类似物
• 英文名称: Radicicol A
• 英文别名: (4S,6Z,9S,10S,12E)-9,10,18-trihydroxy-15,16-dimethoxy-4-methyl-3-oxabicyclo[12.4.0]octadeca-1(14),6,12,15,17-pentaene-2,8-dione
• CAS: 160191-26-4
• 化学式: C₂₀H₂₄O₈
• 分子量: 392.406
• InChiKey: WLZACFNYSRUSIX-ALVJBBJGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  28
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  123
• 氢给体数：
  3
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  Radicicol A 在 10% Pd/C 、 氢气 作用下， 以 四氢呋喃 为溶剂， 生成 (7S,12S,13S)-4,12,13-Trihydroxy-1,2-dimethoxy-7-methyl-7,8,9,10,13,14,15,16-octahydro-12H-6-oxa-benzocyclotetradecene-5,11-dione
  参考文献：
  名称：

  Novel cyclopropyl diketones and 14-membered macrolides from the soil fungus Hamigera avellanea BCC 17816

  摘要：

  Two novel cyclopropyl diketones, hamavellone A (1) and B (2), and two new 14-membered nonaketide macrolactones, hamigeromycin A (3) and B (4), together with six known compounds, 89-250904-F1 (radicicol analogue A, 5), pseurotin A (6), emodin (7), omega-hydroxyemodin (8), and emodin bianthrones (9 and 10) were isolated from the soil fungus Hamigera avellanea BCC 17816. The structures of the new compounds were defined by analysis of NMR and MS data. The absolute stereochemistry of 3 was addressed by chemical correlation to 5. Hamavellone B (2) exhibited antimalarial activity with an IC50 of 5.2 mu g/nnL, whereas it also showed comparable cytotoxicity. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2008.09.077
• 作为产物：
  描述：

  (4S,6Z,9S,10S,12E)-8,9,10,18-tetrahydroxy-15,16-dimethoxy-4-methyl-3-oxabicyclo[12.4.0]octadeca-1(14),6,12,15,17-pentaen-2-one 在 polymer-bound 2-iodoxybenzoic acid 作用下， 以 二氯甲烷 为溶剂， 反应 1.0h， 以90%的产率得到Radicicol A
  参考文献：
  名称：

  Radicicol A和相关间苯二酸内酯（有效的激酶抑制剂）的模块化合成。

  摘要：

  DOI：

  10.1002/anie.200702406

文献信息

• Compositions And Methods Comprising Analogues Of Radicicol A
  申请人：Winssinger Nicolas

  公开号：US20100233279A1

  公开（公告）日：2010-09-16

  Disclosed are novel analogues of the natural product radicicol A of formulae I, .Ia, pi, Ha, lib and HI, pharmaceutical compositions comprising the compounds. The compounds of the invention are kinase and phosphatase inhibitors and find utility in the treatment or prevention of kinase and phosphatase-mediated disorders. Also provided are uses and methods for the treatment or prevention of kinase- and phosphatase-mediated disorders and synthetic processes for the preparation of the compounds.

  本发明涉及天然产物radicicol A的新型类似物，其化学式为I、Ia、pi、Ha、lib和HI，以及包含这些化合物的制药组合物。本发明中的化合物是激酶和磷酸酶抑制剂，在治疗或预防激酶和磷酸酶介导的疾病中具有应用价值。本发明还提供了治疗或预防激酶和磷酸酶介导的疾病的用途和方法，以及合成这些化合物的方法。
• STABLY TRANSFECTED CELLS FOR IDENTIFYING COMPOUNDS WHICH AFFECT STABILITY OF mRNA
  申请人：Novation Pharmaceuticals Inc.

  公开号：EP1141358B1

  公开（公告）日：2007-12-05
• MACROCYCLIC COMPOUNDS USEFUL AS INHIBITORS OF KINASES AND HSP90
  申请人：Université de Strasbourg

  公开号：EP2136799B1

  公开（公告）日：2017-10-04
• Assay for identifying compounds which affect stability of mrna
  申请人：Katelic Tania

  公开号：US20070190532A1

  公开（公告）日：2007-08-16

  The present invention relates to an assay for the identification of biologically active compounds, in particular to a reporter gene assay for the identification of compounds, which have an effect on mRNA stability. More particularly, the present invention relates to a reporter gene expression system and cell lines comprising said expression system. The invention further relates to compounds which destabilise mRNA.
• ASSAY FOR IDENTIFYING COMPOUNDS WHICH AFFECT STABILITY OF MRNA
  申请人：Kastelic Tania

  公开号：US20090068654A1

  公开（公告）日：2009-03-12

  The present invention relates to an assay for the identification of biologically active compounds, in particular to a reporter gene assay for the identification of compounds, which have an effect on mRNA stability. More particularly, the present invention relates to a reporter gene expression system and cell lines comprising said expression system. The invention further relates to compounds which destabilise mRNA.