(3R,5R)-3,5-Dihydroxyhexanoic acid | 821772-70-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羟基酸及其衍生物
• 英文名称: (3R,5R)-3,5-Dihydroxyhexanoic acid
• CAS: 821772-70-7
• 化学式: C₆H₁₂O₄
• 分子量: 148.16
• InChiKey: RUSJDZRTPDUURW-RFZPGFLSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.8
• 重原子数：
  10
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  77.8
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• PROCESS FOR THE PREPARATION OF STATINS IN THE PRESENCE OF BASE
  申请人：Bessembinder Karin Henderika Maria

  公开号：US20130296561A1

  公开（公告）日：2013-11-07

  The present invention relates to a process for the preparation of statins by means of a Julia-Kocienski reaction between an aldehyde and a sulfone derivative in the presence of an alkaline metal alkoxy base. The resulting derivatives are suitable as building blocks for statin type compounds such as cerivastatin, fluvastatin, pitavastatin and rosuvastatin.

  本发明涉及一种通过在碱性金属烷氧基存在下，通过醛和磺酮衍生物之间的Julia-Kocienski反应制备他汀类药物的方法。所得衍生物适用于他汀类化合物的构建模块，如西立伐他汀、氟伐他汀、匹伐他汀和罗伐他汀。
• CHEMOENZYMATIC METHODS FOR THE SYNTHESIS OF STATINS AND STATIN INTERMEDIATES
  申请人：GREENBERG William

  公开号：US20080289056A1

  公开（公告）日：2008-11-20

  The invention provides aldolases, nucleic acids encoding them and methods for making and using them, including chemoenzymatic processes for making β,δ-dihydroxyheptanoic acid side chains and compositions comprising these side chains, e.g., [R—(R*,R*)]-2-(4-fluorophenyl)-b,d-dihydroxy-5-(1-methylethyl)-3-phenyl-4-(phenylamino)-carbonyl]-1H-pyrrole-1-heptanoic acid (atorvastatin, LIPITOR™), rosuvastatin (CRESTOR™), fluvastatin (LESCOL™), related compounds and their intermediates.
• Polymeric Bioplastics
  申请人：Clardy Jon C.

  公开号：US20110009593A1

  公开（公告）日：2011-01-13

  One aspect of the present invention relates to a polymeric material. The invention also relates to a method of making the aforementioned polymer comprising extracting a fungus, wherein the fungus is, for example, an endophytic fungus, such as CR873. The invention further relates to a bioplastic composition comprising the aforementioned polymer.
• TREATING CANCER WITH STATINS AND COMPOUNDS HAVING DIPYRIDAMOLE ACTIVITY
  申请人：Penn Linda

  公开号：US20130131088A1

  公开（公告）日：2013-05-23

  The disclosure pertains to methods of treating a cancer comprising administering to a subject in need thereof an effective amount of a statin in combination with an effective amount of a dipyridamole and/or a compound that has dipyridamole activity.
• US7371759B2
  申请人：——

  公开号：US7371759B2

  公开（公告）日：2008-05-13