[Ag(methyl isonicotinate)2](nitrate)*water | 946607-50-7

• 分子结构分类: 有机化合物 - 有机杂环化合物
• 英文名称: [Ag(methyl isonicotinate)2](nitrate)*water
• CAS: 946607-50-7
• 化学式: C₁₄H₁₄AgN₂O₄*H₂O*NO₃
• 分子量: 462.165
• InChiKey: RTNHAZJLIRVSGU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
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• 氢受体数：
  None

反应信息

• 作为产物：
  描述：

  异烟酸甲酯 、 水 、 silver nitrate 以 乙醇 、 水 为溶剂， 以90%的产率得到[Ag(methyl isonicotinate)2](nitrate)*water
  参考文献：
  名称：

  Synthesis and Structure of Silver Complexes with Nicotinate-Type Ligands Having Antibacterial Activities against Clinically Isolated Antibiotic Resistant Pathogens

  摘要：

  The synthesis and low-temperature X-ray crystal structures of five new silver complexes, [Ag-2-mu-O,O '(2-aminonicotinium)(2)(NO3)(2)](n) (7), [Ag(isonicotinamide)(2)-mu-O,O'(NO3)](2) (8), [Ag(ethyl nicotinate)(2)](NO3) (9), [Ag(ethyl isonicotinate)(2)(NO3)] (10), and [Ag(methyl isonicotinate)(2)(H2O)](NO3) (11), are presented and fully characterized by spectral and elemental analysis. The antimicrobial activities of these complexes were screened using 12 different clinical isolates belonging to four pathogenic bacteria, S. aureus, S. pyogenes, P. mirabilis, and Ps. Aeruginosa, all obtained from diabetic foot ulcers. These tested bacteria were resistant for at least 10 antibiotics commonly used for treatment of diabetic foot ulcers. Compounds 7 and 8 had considerable activity against Ps. Aeruginosa (MIC values 2-8 mu g/mL), compound 9 against S. aureus (MIC 4-16 mu g/mL) and S. pyogenes (MIC 2-4 mu g/mL), and also 9 and 11 against P. mirabilis (MIC 1-16 mu g/mL). All complexes were non-toxic for daphnia at concentrations above 512 mu g/mL overnight.

  DOI：

  10.1021/ic0621594