(S)-2-methyl-3-cyclohexyl-propionic acid | 51953-02-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (S)-2-methyl-3-cyclohexyl-propionic acid
• 英文别名: (S)-2-Methyl-3-cyclohexyl-propionsaeure；(2S)-3-cyclohexyl-2-methylpropanoic acid
• CAS: 51953-02-7
• 化学式: C₁₀H₁₈O₂
• 分子量: 170.252
• InChiKey: SAOPJNFYPNUPSE-QMMMGPOBSA-N

物化性质

• 沸点：
  136 °C(Press: 1 Torr)
• 密度：
  0.978 g/cm3(Temp: 25 °C)

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  乙醇 、 (S)-2-methyl-3-cyclohexyl-propionic acid 在 硫酸 作用下， 生成 ethyl (2S)-3-cyclohexyl-2-methylpropanoate
  参考文献：
  名称：

  Levene; Marker, Journal of Biological Chemistry, 1935, vol. 110, p. 299,303

  摘要：

  DOI：
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 溶剂黄146 、 铂 作用下， 生成 (S)-2-methyl-3-cyclohexyl-propionic acid
  参考文献：
  名称：

  Levene; Marker, Journal of Biological Chemistry, 1935, vol. 110, p. 299,303

  摘要：

  DOI：

文献信息

• IDENTIFICATION OF COMPOUNDS MODIFYING A CELLULAR RESPONSE
  申请人：Thastrup Ole

  公开号：US20130123140A1

  公开（公告）日：2013-05-16

  The present invention relates to methods for identifying compounds capable of modulating a cellular response. The methods involve attaching living cells to solid supports comprising a library of test compounds. The test compounds are linked to the solid support via cleavable linkers and may thus be released from the solid supports. Solid supports comprising cells, wherein the cellular response of interest has been modulated are selected and the test compound of the solid support can then be identified. The cellular response may for example be changes in complex formation between proteins.

  本发明涉及识别能够调节细胞响应的化合物的方法。该方法包括将活细胞附着在包含一系列测试化合物的固体支持物上。测试化合物通过可切断的连接物与固体支持物相连，因此可以从固体支持物中释放出来。选择细胞响应已被调节的固体支持物，并可以鉴定固体支持物中的测试化合物。例如，细胞响应可以是蛋白质之间复合物形成的变化。
• TRIPEPTIDE EPOXY KETONE PROTEASE INHIBITORS
  申请人：Onyx Therapeutics, Inc.

  公开号：US20160368946A1

  公开（公告）日：2016-12-22

  Provided herein are tripeptide epoxy ketone protease inhibitors, methods of their preparation, related pharmaceutical compositions, and methods of using the same. For example, provided herein are compounds of Formula (X): and pharmaceutically acceptable salts and compositions including the same. The compounds and compositions provided herein may be used, for example, in the treatment of diseases including inflammation and neurodegenerative disease.
• US9150899B2
  申请人：——

  公开号：US9150899B2

  公开（公告）日：2015-10-06
• US9434761B2
  申请人：——

  公开号：US9434761B2

  公开（公告）日：2016-09-06
• [EN] ANTI-GM1 ANTIBODY BINDING COMPOUNDS<br/>[FR] COMPOSÉS DE LIAISON À UN ANTICORPS ANTI-GM1
  申请人：[en]POLYNEURON PHARMACEUTICALS AG

  公开号：WO2022224035A2

  公开（公告）日：2022-10-27

  This disclosure provides glycan-conjugated compounds that specifically bind to anti -GM1 autoantibodies. These glycan-conjugated compounds can include a polymer backbone or support configured to display multiple glycan groups that are designed to mimic the natural GM1 epitope. The glycan-conjugated compounds can also be configured on a solid support. The linked glycan groups can be a novel analogue of the GM1 epitope. When several such glycan groups are configured on a polymeric backbone, the resulting compound provides for potent and specific binding to anti-GM1 IgG and IgM isotype autoantibodies in patient sera. This disclosure thus provides glycan-containing compounds of formula (I) that mimic the natural GM1 epitope, and therapeutically useful polymers that include a multitude of such ligands, designed to bind anti-GM1 antibodiesin vitrofor diagnostic use, and to sequester and eliminate anti-GM1 antibodiesin vivoor extracorporeal (ex vivo) for the treatment anti-GM1 autoantibody related neuropathies.