3-苄氧基哌啶 | 1185304-22-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 3-苄氧基哌啶
• 中文别名: 3-苄氧基哌啶盐酸盐
• 英文名称: 3-(benzyloxy)piperidine hydrochloride
• 英文别名: 3-phenylmethoxypiperidine;hydrochloride
• CAS: 1185304-22-6
• 化学式: C₁₂H₁₇NO*ClH
• 分子量: 227.734
• InChiKey: QFNCCBWLSWYFKN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.38
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  21.3
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3-苄氧基哌啶 在 potassium carbonate 作用下， 以 四氢呋喃 为溶剂， 反应 14.0h， 以37.8%的产率得到2-(3-(benzyloxy)piperidin-1-yl)-6-bromo-5-chlorothiazolo[4,5-b]pyridine
  参考文献：
  名称：

  BICYCLIC HETEROCYCLYL DERIVATES AS IRAK4 INHIBITORS

  摘要：

  本发明提供了公式（I）的双环杂环基激酶酶抑制剂化合物，作为激酶抑制剂在治疗上具有疗效，特别是IRAK4抑制剂，在其中A、Y、Z、X1、X2、R1、R3、‘m’、‘n’和‘p’的含义如规范中所给定，并且在治疗和预防疾病或紊乱方面有用，特别是在通过激酶酶介导的疾病或紊乱中的使用，特别是IRAK4酶。本发明还提供了包含至少一种公式（I）的化合物的制剂，与其一起使用的药用载体、稀释剂或赋形剂。

  公开号：

  US20160340366A1

文献信息

• [EN] SUBSTITUTED CARBAMATE COMPOUNDS AND THEIR USE AS TRANSIENT RECEPTOR POTENTIAL (TRP) CHANNEL ANTAGONISTS<br/>[FR] COMPOSÉS CARBAMATE SUBSTITUÉS ET LEUR UTILISATION EN TANT QU'ANTAGONISTES DU CANAL POTENTIEL RÉCEPTEUR TRANSITOIRE (TRP)
  申请人：HOFFMANN LA ROCHE

  公开号：WO2014060341A1

  公开（公告）日：2014-04-24

  The invention is concerned with the compounds of formula (I): and pharmaceutically acceptable salts thereof, wherein Y, R1 and R3 are defined in the detailed description and claims. In addition, the present invention relates to methods of manufacturing and using the compounds of formula (I) as well as pharmaceutical compositions containing such compounds. The compounds of formula (I) are antagonists of the TRPA1 channel and may be useful in treating inflammatory diseases and disorders associated with that channel.

  该发明涉及式(I)的化合物及其药学上可接受的盐，其中Y、R1和R3在详细描述和权利要求中有定义。此外，本发明涉及制备和使用式(I)的化合物的方法，以及含有这些化合物的药物组合物。式(I)的化合物是TRPA1通道的拮抗剂，可能对治疗与该通道相关的炎症性疾病和紊乱有用。
• [EN] BICYCLIC HETEROCYCLYL DERIVATIVES AS IRAK4 INHIBITORS<br/>[FR] DÉRIVÉS HÉTÉROCYCLYLES BICYCLIQUES COMME INHIBITEURS DE IRAK4
  申请人：AURIGENE DISCOVERY TECH LTD

  公开号：WO2015104688A1

  公开（公告）日：2015-07-16

  The present invention provides bicyclic heterocyclyl kinase enzyme inhibitor compounds of formula (I), which are therapeutically useful as kinase inhibitors, particularly IRAK4 inhibitors. wherein A, Y, Z, X1, X2, X3, R1, R3, 'm', 'n' and 'p' have the meanings given in the specification and pharmaceutically acceptable salt or stereoisomer thereof that are useful in the treatment and prevention of diseases or disorder, in particular their use in diseases or disorder mediated by kinase enzyme, particularly IRAK4 enzyme. The present invention also provides pharmaceutical composition comprising at least one of the compounds of compound of formula (I) together with a pharmaceutically acceptable carrier, diluent or excipient therefor.

  本发明提供了式（I）的双环杂环基激酶酶抑制剂化合物，其作为激酶抑制剂在治疗上具有疗效，特别是IRAK4抑制剂。其中A、Y、Z、X1、X2、X3、R1、R3、'm'、'n'和'p'在规范中给出了含义，并且具有治疗和预防疾病或疾病的药用盐或其立体异构体，在特定情况下用于由激酶酶介导的疾病或疾病的治疗。本发明还提供了包括至少一种式（I）化合物的药物组合物，与药用载体、稀释剂或赋形剂一起。
• SUBSTITUTED CARBAMATE COMPOUNDS
  申请人：HOFFMANN-LA ROCHE INC

  公开号：US20150218141A1

  公开（公告）日：2015-08-06

  The invention is concerned with the compounds of formula (I): and pharmaceutically acceptable salts thereof, wherein Y, R1 and R3 are defined in the detailed description and claims. In addition, the present invention relates to methods of manufacturing and using the compounds of formula (I) as well as pharmaceutical compositions containing such compounds. The compounds of formula (I) are antagonists of the TRPA1 channel and may be useful in treating inflammatory diseases and disorders associated with that channel.

  本发明涉及式(I)的化合物及其药学上可接受的盐，其中Y、R1和R3在详细说明和权利要求中有定义。此外，本发明还涉及制造和使用式(I)化合物的方法，以及含有这些化合物的制药组合物。式(I)化合物是TRPA1通道的拮抗剂，可能有助于治疗与该通道相关的炎症性疾病和障碍。
• METHOD OF PREPARING OXAZOLO[4,5-B]PYRIDINE AND THIAZOLO[4,5-B]PYRIDINE DERIVATIVES AS IRAK4 INHIBITORS FOR TREATING CANCER
  申请人：Aurigene Discovery Technologies Limited

  公开号：EP3466955A1

  公开（公告）日：2019-04-10

  The present invention provides bicyclic heterocyclyl kinase enzyme inhibitor compounds of formula (I), which are therapeutically useful as kinase inhibitors, particularly IRAK4 inhibitors. wherein A, Y, Z, X1, X2, X3, R1, R3, 'm', 'n' and 'p' have the meanings given in the specification and pharmaceutically acceptable salt or stereoisomer thereof that are useful in the treatment and prevention of diseases or disorder, in particular their use in diseases or disorder mediated by kinase enzyme, particularly IRAK4 enzyme. The present invention also provides pharmaceutical composition comprising at least one of the compounds of formula (I) together with a pharmaceutically acceptable carrier, diluent or excipient therefor.

  本发明提供了式(I)的双环杂环激酶酶抑制剂化合物，它们作为激酶抑制剂，特别是IRAK4抑制剂，具有治疗作用。 其中A、Y、Z、X1、X2、X3、R1、R3、'm'、'n'和'p'具有说明书中给出的含义及其药学上可接受的盐或立体异构体，这些化合物对治疗和预防疾病或紊乱有用，特别是它们在激酶酶，尤其是IRAK4酶介导的疾病或紊乱中的用途。本发明还提供由至少一种式（I）化合物及其药学上可接受的载体、稀释剂或赋形剂组成的药物组合物。
• (R) AND (S) ENANTIOMER OF N-(5-(3-HYDROXYPYRROLIDIN-1-YL)-2-MORPHOLINOOXAZOLO[4,5-B]PYRIDIN-6-YL)-2-(2-METHYLPYRIDIN-4-YL)OXAZOLE-CARBOXAMIDE AS IRAK4 INHIBITORS FOR TREATING CANCER AND INFLAMMATORY DISEASES
  申请人：Aurigene Discovery Technologies Limited

  公开号：EP3805233A1

  公开（公告）日：2021-04-14

  Provided are bicyclic heterocyclyl kinase enzyme inhibitor compounds and pharmaceutically acceptable salts thereof that are useful in the treatment and prevention of diseases or disorder, in particular their use in diseases or disorder mediated by kinase enzyme, particularly IRAK4 enzyme, such as e.g. cancer and inflammatory diseases.

  提供双环杂环激酶抑制剂化合物 及其药学上可接受的盐类，可用于治疗和预防疾病或紊乱，特别是用于由激酶，尤其是IRAK4酶介导的疾病或紊乱，例如癌症和炎症性疾病。