ethyl 4-(5-{(1Z,3E)-4-[2-(trifluoromethyl)-10H-phenothiazin-10-yl]buta-1,3-dien-1-yl}-2H-tetrazol-2-yl)benzoate | 1442372-26-0

• 分子结构分类: 有机化合物 - 有机杂环化合物
• 英文名称: ethyl 4-(5-{(1Z,3E)-4-[2-(trifluoromethyl)-10H-phenothiazin-10-yl]buta-1,3-dien-1-yl}-2H-tetrazol-2-yl)benzoate
• CAS: 1442372-26-0
• 化学式: C₂₇H₂₀F₃N₅O₂S
• 分子量: 535.549
• InChiKey: IWQKHQMYISLFMR-DNGQKCCQSA-N

反应信息

• 作为反应物：
  描述：

  ethyl 4-(5-{(1Z,3E)-4-[2-(trifluoromethyl)-10H-phenothiazin-10-yl]buta-1,3-dien-1-yl}-2H-tetrazol-2-yl)benzoate 在 dimethyl sulfide borane 、 甲醇 作用下， 以 四氢呋喃 为溶剂， 反应 528.0h， 以19%的产率得到ethyl 4-(5-{3-hydroxy-4-[2-(trifluoromethyl)-10H-phenothiazin-10-yl]butyl}-2H-tetrazol-2-yl)benzoate
  参考文献：
  名称：

  Synthesis and pharmacological investigation of new N-hydroxyalkyl-2-aminophenothiazines exhibiting marked MDR inhibitory effect

  摘要：

  Novel N-hydroxyalkyl-2-aminophenothiazines implying a tetrazole moiety at the alkyl chain have been synthesized by hydroboration oxidation of dienes followed by Buchwald Hartwig cross-coupling reaction. Also, some sulfoxide and sulfone derivatives have been prepared by selective oxidations. MDR inhibition studies on rat hepatocyte cell culture revealed that some derivatives exhibit marked biological efficacy exceeding that of the standard verapamil (e.g., 3h, 4h, 16). Selected derivatives were subjected to chemical resolution to provide both enantiomers which were shown of similar activity on P-gp interaction measurements. The new compounds exhibited no toxicity. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2013.04.034