(S)-1-(2-(carboxymethoxy)-5-chlorophenyl)-5,6-difluoro-3,4-dihydro-1H-isoquinoline-2-carboxylic acid 2-(3,5-dimethylpyrazol-1-yl)ethyl ester | 1355056-90-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: (S)-1-(2-(carboxymethoxy)-5-chlorophenyl)-5,6-difluoro-3,4-dihydro-1H-isoquinoline-2-carboxylic acid 2-(3,5-dimethylpyrazol-1-yl)ethyl ester
• 英文别名: 2-[4-chloro-2-[(1S)-2-[2-(3,5-dimethylpyrazol-1-yl)ethoxycarbonyl]-5,6-difluoro-3,4-dihydro-1H-isoquinolin-1-yl]phenoxy]acetic acid
• CAS: 1355056-90-4
• 化学式: C₂₅H₂₄ClF₂N₃O₅
• 分子量: 519.932
• InChiKey: CKSJWFUEELMPLD-DEOSSOPVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  36
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  93.9
• 氢给体数：
  1
• 氢受体数：
  8

文献信息

• [EN] 1-PHENYL-SUBSTITUTED HETEROCYCLYL DERIVATIVES AND THEIR USE AS PROSTAGLANDIN D2 RECEPTOR MODULATORS<br/>[FR] DÉRIVÉS D'HÉTÉROCYCLYLE SUBSTITUÉS PAR UN 1-PHÉNYLE ET LEUR UTILISATION EN TANT QUE MODULATEURS DES RÉCEPTEURS DE LA PROSTAGLANDINE D2
  申请人：ACTELION PHARMACEUTICALS LTD

  公开号：WO2012004722A1

  公开（公告）日：2012-01-12

  302 Abstract The present invention relates to 1-phenyl-substituted heterocyclyl derivatives of the formula (I), O Y R 5 R 6 N R 2 R 3 R 4 X Z R 1 R 7 R 7 R 10 n (I) 5 wherein X, Y, Z, n, R 1, R 2, R 3, R 4, R 5, R 6, R 7 and R 10 are as described in the description and their use as prostaglandin receptor modulators, most particularly as prostaglandin D 2 receptor modulators, in the treatment of various prostaglandin-mediated diseases and disorders, to pharmaceutical compositions containing these compounds and to processes for their preparation. 10

  本发明涉及公式(I)的1-苯基取代的杂环基衍生物，其中X、Y、Z、n、R1、R2、R3、R4、R5、R6、R7和R10如描述中所述，并且它们作为前列腺素受体调节剂的用途，特别是作为前列腺素D2受体调节剂，在治疗各种前列腺素介导的疾病和紊乱中的用途，以及含有这些化合物的制药组合物和其制备方法。
• 1-PHENYL-SUBSTITUTED HETEROCYCLYL DERIVATIVES AND THEIR USE AS PROSTAGLANDIN D2 RECEPTOR MODULATORS
  申请人：Aissaoui Hamed

  公开号：US20130109685A1

  公开（公告）日：2013-05-02

  The present invention relates to 1-phenyl-substituted heterocyclyl derivatives of the formula (I), wherein X, Y, Z, n, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 and R 10 are as described in the description and their use as prostaglandin receptor modulators, most particularly as prostaglandin D 2 receptor modulators, in the treatment of various prostaglandin-mediated diseases and disorders, to pharmaceutical compositions containing these compounds and to processes for their preparation.

  本发明涉及公式（I）中1-苯基取代的杂环基衍生物，其中X、Y、Z、n、R1、R2、R3、R4、R5、R6、R7和R10如描述中所述，以及它们在各种前列腺素介导的疾病和疾病的治疗中作为前列腺素受体调节剂，特别是作为前列腺素D2受体调节剂的用途，以及包含这些化合物的制药组合物和它们的制备方法。
• US8575158B2
  申请人：——

  公开号：US8575158B2

  公开（公告）日：2013-11-05