| 141090-65-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 四吡咯及其衍生物
• CAS: 141090-65-5
• 化学式: C₄₀H₄₂N₄O₈
• 分子量: 706.795
• InChiKey: YMUGLHJGNFOKHV-LHPWBCDESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.73
• 重原子数：
  52.0
• 可旋转键数：
  10.0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  162.56
• 氢给体数：
  2.0
• 氢受体数：
  10.0

反应信息

• 作为反应物：
  描述：

  Galactosamine 、 在 三乙胺 作用下， 以 四氢呋喃 、 乙醇 、 水 为溶剂， 反应 12.0h， 生成 protoporphyrin 13³,17³-bis(2-amido-2-desoxy-α,β-D-galactopyranosid)
  参考文献：
  名称：

  具有 2-氨基糖酰胺头基的手性胶束卟啉纤维

  摘要：

  易于获得的原卟啉 IX 13,17-双（糖酰胺）形成胶体水溶液，可稳定数月或更长时间。电子显微照片显示宽度约为 4 nm，长度介于 20 nm（D-葡糖酰胺）和 5 μm（D,L-甘露糖酰胺）之间的色带。在一种情况下，应用凝胶色谱法以获得分子量，对于约90%的胶体颗粒，分子量被确定为≥2×10 6 D。水性悬浮液的 UV-vis 光谱显示 Soret 谱带，该谱带被激子相互作用（460 和 360 nm）分开约 100 nm

  DOI：

  10.1021/ja00037a018
• 作为产物：
  描述：

  氯甲酸乙酯 、 protoporphyrin IX 在 N-甲基吗啉 作用下， 以 氯仿 为溶剂， 反应 0.5h， 生成
  参考文献：
  名称：

  The Design of Multifunctional Antioxidants Against the Damaging Ingredients of Oxidative Stress

  摘要：

  Oxidative stress is a biochemical condition associated with a sharp increase in intracellular concentrations of a range of oxidative stressors, including reactive oxygen species, reactive nitrogen species and labile metal ions. It is associated with a wide range of human disorders, such as inflammatory diseases, neurodegenerative diseases, glaucoma, and cancer. Equally importantly, oxidative stress is pronounced in older people, which makes it an important matter in an ageing Society. Not surprisingly, antioxidants have become a major focus of modern drug development. While natural antioxidants, such as phenolic aromatic compounds, vitamin C, vitamin E and curcumin have shown promising results, the development of effective synthetic antioxidants is often problematic. We have recently proposed the rational design of multifunctional antioxidants which target oxidative stressors in a more comprehensive manner. Such compounds may, for instance, combine catalytic sites with metal binding sites. Here we present the synthesis of representative molecules with combined catalytic and metal binding properties. The apparent 'antioxidant' activities have been studied in vitro and, for the most promising compound, have been confirmed in cultured skin cells exposed to UVA radiation.

  DOI：

  10.1080/10426500801898200

文献信息

• ANTITUMOR AGENTS AND PROCESS FOR PRODUCING THE SAME
  申请人：Maeda, Hiroshi

  公开号：EP1421938B1

  公开（公告）日：2010-02-03