| 1136103-10-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• CAS: 1136103-10-0
• 化学式: C₃₂H₃₆F₄N₄O₆S₂
• 分子量: 712.787
• InChiKey: ZSBBNVKFXKZFBE-ZEZDXWPOSA-N

反应信息

• 作为产物：
  描述：

  在 草酰氯 、 二甲基亚砜 作用下， 以 二氯甲烷 为溶剂， 生成 、
  参考文献：
  名称：

  Investigation of ketone warheads as alternatives to the nitrile for preparation of potent and selective cathepsin K inhibitors

  摘要：

  Amino ketone warheads were explored as alternatives to the nitrile group of a potent and selective cathepsin K inhibitor. The resulting compounds were potent and selective inhibitors of cathepsin K and these nitrile replacements had a significant effect on metabolism and pharmacokinetics. (c) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.12.053