3-(1H-imidazol-5-yl)-N-methylpropanamide | 124370-06-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 3-(1H-imidazol-5-yl)-N-methylpropanamide
• CAS: 124370-06-5
• 化学式: C₇H₁₁N₃O
• 分子量: 153.18
• InChiKey: JQJMRJAUNPWLBB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.4
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  57.8
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• Amine Cationic Lipids and Uses Thereof
  申请人：Dicerna Pharmaceuticals, Inc.

  公开号：US20140371293A1

  公开（公告）日：2014-12-18

  The present invention relates to lipid compounds and uses thereof. In particular, the compounds include a class of cationic lipids having an amine moiety, such as an amino-amine or an amino-amide moiety. The lipid compounds are useful for in vivo or in vitro delivery of one or more agents (e.g., a polyanionic payload or an antisense payload, such as an RNAi agent).

  本发明涉及脂质化合物及其用途。具体而言，这些化合物包括一类具有胺基团的阳离子脂质，例如氨基-胺或氨基-酰胺基团。这些脂质化合物可用于体内或体外传递一个或多个药物（例如，多聚阴离子荷载物或反义荷载物，如RNAi药物）。
• AMINE CATIONIC LIPIDS AND USES THEREOF
  申请人：Dicerna Pharmaceuticals, Inc.

  公开号：EP3960726A1

  公开（公告）日：2022-03-02

  The present invention relates to lipid compounds and uses thereof. In particular, the compounds include a class of cationic lipids having an amine moiety, such as amino-amide moiety. The lipid compounds are useful for in vivo or in vitro delivery of one or more agents ( e.g. a polyanionic payload or an antisense payload, such as an RNAi agent).

  本发明涉及脂质化合物及其用途。特别是，这些化合物包括一类具有胺分子（如氨基酰胺分子）的阳离子脂质。这些脂质化合物可用于体内或体外递送一种或多种制剂（如多阴离子有效载荷或反义有效载荷，如 RNAi 制剂）。
• Novel GLP-1 compounds
  申请人：Johansen Langeland Nils

  公开号：US20070042956A1

  公开（公告）日：2007-02-22

  Novel GLP-1 compounds and their therapeutic use.
• PROCESS FOR FORMULATING AN ANIONIC AGENT
  申请人：Dicerna Pharmaceuticals, Inc.

  公开号：US20150374842A1

  公开（公告）日：2015-12-31

  Formulations comprising anionic agents such as nucleic acids within a lipid-containing particle methods of formulating a lipid-containing particle comprising an anionic agent such as a nucleic acid, methods for preparing a lipid-containing particle comprising an anionic agent such as a nucleic acid, methods for therapeutic delivery of an anionic agent to a patient in need thereof, where the anionic agent is formulated in a lipid-containing particle as described herein.
• US9549983B2
  申请人：——

  公开号：US9549983B2

  公开（公告）日：2017-01-24