2-hydroxy-4'-methoxy-4-methylbenzophenone | 108478-27-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-hydroxy-4'-methoxy-4-methylbenzophenone
• 英文别名: 2-Hydroxy-4'-methoxy-4-methyl-benzophenon；(2-Hydroxy-4-methylphenyl)(4-methoxyphenyl)methanone；(2-hydroxy-4-methylphenyl)-(4-methoxyphenyl)methanone
• CAS: 108478-27-9
• 化学式: C₁₅H₁₄O₃
• 分子量: 242.274
• InChiKey: ZOZSCTGNLGEROS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  m-tolyl 4-methoxybenzoate 在 三氯化铝 作用下， 生成 2-hydroxy-4'-methoxy-4-methylbenzophenone
  参考文献：
  名称：

  Gupta; Saharia, Journal of the Indian Chemical Society, 1958, vol. 35, p. 133

  摘要：

  DOI：

文献信息

• Direct Acylation of Phenol and Naphthol Derivatives in a Mixture of Graphite and Methanesulfonic Acid
  作者：Hashem Sharghi、Mona Hosseini-Sarvari、Razieh Eskandari

  DOI：10.1055/s-2006-942384

  日期：2006.6

  Graphite in methanesulfonic acid is used to prepare o-hydroxyketones by direct acylation of phenol and naphthol derivatives with carboxylic acids.

  甲磺酸中的石墨用于通过苯酚和萘酚衍生物与羧酸的直接酰化来制备邻羟基酮。
• Cellulose Acylate Film, Method of Producing the Same, Cellulose Derivative Film, Optically Compensatory Film Using the Same, Optically-Compensatory Film Incorporating Polarizing Plate, Polarizing Plate and Liquid Crystal Display Device
  申请人：Haruta Hiromoto

  公开号：US20090290100A1

  公开（公告）日：2009-11-26

  A method of producing a cellulose derivative film, the method comprising: forming a film with a solvent cast method from a dope including a cellulose derivative satisfying following conditions (a) and (b): (a) at least one among three hydroxyl groups included in a glucose unit of cellulose is substituted by a substituent of which a polarizability anisotropy Δα represented as following Expression (1) is 2.5×10 −24 cm 3 or higher: Expression (1): Δα=αx−(αy+αz)/2, wherein αx, αy and αz is as defined in the specification; and (b) when a substitution degree by a substituent of which Δα is 2.5×10 −24 cm 3 or higher is P A , and a substitution degree by a substituent of which Δα is lower than 2.5×10 −24 cm 3 is P B , the P A and P B satisfy following Expressions (3) and (4): Expression (3): 2P A +P B >3.0; and Expression (4): P A >0.2.

  一种生产纤维素衍生物薄膜的方法，该方法包括：使用包括满足以下条件（a）和（b）的纤维素衍生物的溶胶，通过溶剂浇铸法形成薄膜：（a）纤维素的葡萄糖单元中的三个羟基中的至少一个被取代为极化率各向异性Δα（以下表达式（1）表示）为2.5×10-24cm3或更高的取代基：表达式（1）：Δα=αx-（αy+αz）/ 2，其中αx，αy和αz如规范中定义的；并且（b）当Δα为2.5×10-24cm3或更高的取代基的取代度为PA时，Δα低于2.5×10-24cm3的取代基的取代度为PB，PA和PB满足以下表达式（3）和（4）：表达式（3）：2PA + PB> 3.0；表达式（4）：PA> 0.2。
• Regioselective Hydroxylation of Unsymmetrical Ketones Using Cu, H₂O₂, and Imine Directing Groups via Formation of an Electrophilic Cupric Hydroperoxide Core
  作者：Shuming Zhang、Sunipa Goswami、Karl H. G. Schulz、Karan Gill、Xinyi Yin、Jimin Hwang、Jasmine Wiese、Isabel Jaffer、Roberto R. Gil、Isaac Garcia-Bosch

  DOI：10.1021/acs.joc.3c02647

  日期：2024.2.16

  Herein, we describe the regioselective functionalization of unsymmetrical ketones using imine directing groups, Cu, and H2O2. The C–H hydroxylation of the substrate–ligands derived from 2-substituted benzophenones occurred exclusively at the γ-position of the unsubstituted ring due to the formation of only one imine stereoisomer. Conversely, the imines derived from 4-substituted benzophenones produced

  在此，我们描述了使用亚胺导向基团、Cu 和 H 2 O 2对不对称酮进行区域选择性官能化。由于仅形成一种亚胺立体异构体，源自 2-取代二苯甲酮的底物配体的 C-H 羟基化仅发生在未取代环的 γ 位。相反，衍生自4-取代二苯甲酮的亚胺产生E / Z混合物，与Cu和H 2 O 2反应后产生两个γ-C-H羟基化产物。与我们最初的假设相反，羟基化产物的比例并不取决于E / Z异构体的比例，而是取决于反应性[LCuOOH] 1+的亲电性。详细的机理分析表明，在决定速率的亲电子芳香族羟基化之前，结合 CuOOH 核心的亚胺底物-配体发生快速异构化。改变二苯甲酮取代基和/或在导向基团的吡啶4位上引入给电子基团和吸电子基团可以微调单核[LCuOOH] 1+的亲电性，以达到显着的区域选择性（高达91:9 有利于富电子芳环的羟基化）。最后，我们进行了烷基芳基酮的 C-H 羟基化，与不对称二苯甲酮一样，可以通过
• Gupta; Saharia, Journal of the Indian Chemical Society, 1958, vol. 35, p. 133
  作者：Gupta、Saharia

  DOI：——

  日期：——
• Cellulose acylate film, optically compensatory film, polarizing plate and liquid crystal display
  申请人：Nishiura Yosuke

  公开号：US20070059458A1

  公开（公告）日：2007-03-15

  A cellulose acylate film is provided and satisfies the following relationships (I) and (II). The cellulose acylate film has a residual sulfuric acid content of 0 ppm to 100 ppm and contains a release accelerator in an amount of 10 ppm to 2,000 ppm. 0≦ Re (630)≦10 and | Rth (630)|≦25  (I) | Re (400)− Re (700)|≦10 and | Rth (400)− Rth (700)|≦35  (II) Re(λ) is an in-plane retardation value at a wavelength of λ nm, and Rth(λ) is a thickness-direction retardation value at a wavelength of λ nm.