3-苯基-L-丙氨酸钠 | 16480-57-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 3-苯基-L-丙氨酸钠
• 中文别名: 3-苯基-L-丙氨酸酸钠
• CAS: 16480-57-2
• 化学式: C9H11NNaO2
• 分子量: 188.18
• InChiKey: SAHTYPIPYPIKPB-QRPNPIFTSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.26
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  63.3
• 氢给体数：
  2
• 氢受体数：
  3

安全信息

• 海关编码：
  2922499990

文献信息

• Water-soluble mesoporphyrin compounds and methods of preparation
  申请人：——

  公开号：US20040097481A1

  公开（公告）日：2004-05-20

  Water soluble tin mesoporphyrin compounds are described. Methods of preparation of water soluble metal mesoporphyrin compounds and pharmaceutical preparations are also described.

  本文描述了可溶于水的锡中间体卟啉化合物。同时还描述了制备水溶性金属卟啉化合物和制药制剂的方法。
• Ruthenium-phosphine complexes
  申请人：Takasago Perfumery Co., Ltd.

  公开号：EP0245959A2

  公开（公告）日：1987-11-19

  A ruthenium-phosphine complex having a 2,2ʹ-bis(diphenylphosphino)-1,1ʹ-binaphthyl or its derivative as a ligand and carboxyl groups bonded to the ruthenium atom is of the formula: where X is H an amino, acetylamino or sulfo group; R is a H or Cl-4 alkyl; R₁ and R₂ each is a Cl-9 alkyl, halogenated Cl-4 alkyl, phenyl, phenyl substituted with Cl-4 alkyl, Cl-4 α-aminoalkyl, or a C7-10 α-aminophenylalkyl group, or R₁ and R₂ together form a Cl-4 alkylene group; and n is 1 or 2. 17 specific complexes are disclosed. Synthesis is by treatment of a complex wherein the portion outside the bracket is Ru₂Cl₄ . N(C₂H₅)₃ with a carboxylic acid salt.

  以 2,2ʹ-双(二苯基膦)-1,1ʹ-联萘或其衍生物为配体、羧基键合于钌原子的钌膦络合物的结构式为 其中 X 为 H、氨基、乙酰氨基或磺基；R 为 H 或 Cl-4 烷基；R₁ 和 R₂ 各为 Cl-9 烷基、卤代 Cl-4 烷基、苯基、被 Cl-4 烷基取代的苯基、Cl-4 α-氨基烷基或 C7-10 α-氨基苯基烷基，或 R₁ 和 R₂ 共同形成 Cl-4 亚烷基；n 为 1 或 2。 公开了 17 种特定的配合物。 合成方法是处理络合物，其中括号外的部分是 Ru₂Cl₄。N(C₂H₅)₃的羧酸盐。
• Pentaaza macrocyclic ring complexes possessing oral bioavailability
  申请人：Galera Labs, LLC

  公开号：US10597415B2

  公开（公告）日：2020-03-24

  Aspects of the present disclosure relate to compounds which have enhanced oral bioavailability. A transition metal complex includes a transition metal coordinated by a macrocycle comprising the pentaaza 15-membered macrocyclic ring corresponding to Formula A and two axial ligands having the formula —OC(O)X1. each of the two axial ligands has the formula —OC(═O)X1 wherein each X1 is independently substituted or unsubstituted phenyl or —C(—X2)(—X3)(—X4); each X2 is independently substituted or unsubstituted phenyl, or substituted or unsubstituted alkyl; each X3 is independently hydrogen, hydroxyl, alkyl, amino, —X5C(═O)R13 where X5 is NH or O, and R13 is C1-C18 alkyl, substituted or unsubstituted aryl or C1-C18 aralkyl, or —OR14, where R14 is C1-C18 alkyl, substituted or unsubstituted aryl or C1-C18 aralkyl, or together with X4 is (═O); and each X4 is independently hydrogen or together with X3 is (═O).

  本公开的各个方面涉及口服生物利用度提高的化合物。一种过渡金属配合物包括由一个大环配位的过渡金属，该大环包括对应于式 A 的戊氮 15 元大环和两个具有式 -OC(O)X1 的轴向配体。 两个轴向配体中的每个都具有式-OC(═O)X1 其中每个X1独立地是取代或未取代的苯基或-C(-X2)(-X3)(-X4) 每个 X2 独立地是取代或未取代的苯基，或取代或未取代的烷基； 每个 X3 独立地是氢、羟基、烷基、氨基、-X5C(═O)R13（其中 X5 是 NH 或 O，而 R13 是 C1-C18 烷基、取代或未取代的芳基或 C1-C18 芳烷基）或-OR14（其中 R14 是 C1-C18 烷基、取代或未取代的芳基或 C1-C18 芳烷基），或与 X4 一起是 (═O)；和 每个 X4 独立为氢或与 X3 一起为 (═O)。
• Alcohol dehydrogenase mutant and application thereof in cofactor regeneration
  申请人：Jiangnan University

  公开号：US11162124B2

  公开（公告）日：2021-11-02

  Disclosed is an alcohol dehydrogenase mutant and application thereof in cofactor regeneration, and belongs to the technical fields of enzyme engineering and bioengineering. The alcohol dehydrogenase mutant is obtained by mutating valine at position 84 and/or tyrosine at position 127 in alcohol dehydrogenase having an original amino acid sequence as set forth in SEQ ID No. 1. The alcohol dehydrogenase mutant has high activity for a variety of alcohol co-substrates, and can catalyze these enzyme co-substrates for the regeneration of cofactor NADPH. Compared with the wild-type alcohol dehydrogenase KpADH, the alcohol dehydrogenase mutant has higher activity and catalytic efficiency, and for co-substrate 1,4-butanediol, its kcat value can be up to 75.9 min−1, its kcat/Km value can be up to 2009 min−1·M−1, and its Km value can be as low as 11.3 mM. Therefore, the alcohol dehydrogenase mutant has a higher value in industrial application.

  本发明公开了一种醇脱氢酶突变体及其在辅助因子再生中的应用，属于酶工程和生物工程技术领域。该醇脱氢酶突变体是通过突变醇脱氢酶中 84 位的缬氨酸和/或 127 位的酪氨酸而获得的，其原始氨基酸序列如 SEQ ID No.该醇脱氢酶突变体对多种醇类共底物具有高活性，并能催化这些酶的共底物以再生辅助因子 NADPH。与野生型醇脱氢酶 KpADH 相比，醇脱氢酶突变体具有更高的活性和催化效率，对于共底物 1,4-丁二醇，其 kcat 值可达 75.9 min-1，kcat/Km 值可达 2009 min-1-M-1，Km 值可低至 11.3 mM。因此，醇脱氢酶突变体具有更高的工业应用价值。
• [EN] AEROSOL GENERATION OR SMOKING SYSTEM, OR ELECTRONIC CIGARETTE AND DEVICE THEREOF<br/>[FR] SYSTÈME DE GÉNÉRATION D'AÉROSOL OU SYSTÈME À FUMER, OU CIGARETTE ÉLECTRONIQUE ET DISPOSITIF ASSOCIÉ<br/>[ZH] 一种气溶胶生成或烟雾化系统或电子烟及其装置
  申请人：ZHONG SHUGUANG

  公开号：WO2020239083A1

  公开（公告）日：2020-12-03

  一种气溶胶生成材料及使该气溶胶生成材料烟雾化或汽化或气雾化或气溶胶化的装置，该气溶胶生成材料包括含药学上可接受的烟碱盐及药学上可接受的气溶胶或烟雾生成剂的组合物Ⅰ及含药学上可接受的碱性比该烟碱更强的碱（其pKa值大于该烟碱的pKa值）及药学上可接受的气溶胶或烟雾生成剂的组合物Ⅱ，上述组合物Ⅰ及Ⅱ均以烟雾化态或汽化态或气雾态或气溶胶被使用者/消费者吸入。该气溶胶劲头足，生理满足感好，呛喉感低或无，刺激性低或无，过喉性好，烟碱生物利用率高，消费者使用感受良好。