(S)-2-tert-Butoxycarbonylamino-heptanoic acid methyl ester | 92136-53-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (S)-2-tert-Butoxycarbonylamino-heptanoic acid methyl ester
• 英文别名: methyl (2S)-2-[(2-methylpropan-2-yl)oxycarbonylamino]heptanoate
• CAS: 92136-53-3
• 化学式: C₁₃H₂₅NO₄
• 分子量: 259.346
• InChiKey: RUNUKPJHZWNNRB-JTQLQIEISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  18
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.85
• 拓扑面积：
  64.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  (S)-2-amino-4-bromobutyric acid methyl ester 在 copper(l) iodide 作用下， 反应 7.5h， 生成 (S)-2-tert-Butoxycarbonylamino-heptanoic acid methyl ester
  参考文献：
  名称：

  有机酸类化合物合成氨基酸对映体

  摘要：

  在研究有机铜酸盐与L-丝氨酸和L-高丝氨酸的甲苯磺酰基和卤代衍生物的反应过程中，阐述了一种合成光学纯的α-氨基酯的新通用方法。

  DOI：

  10.1016/s0040-4020(01)96546-9

文献信息

• Modified Amino Acids
  申请人：Sutro Biopharma, Inc.

  公开号：US20140066598A1

  公开（公告）日：2014-03-06

  Provided herein are modified amino acids comprising an azido group, polypeptides, antibodies and conjugates comprising the modified amino acids, and methods of producing the polypeptides, antibodies and conjugates comprising the modified amino acids. The polypeptides, antibodies and conjugates are useful in methods of treatment and prevention, methods of detection and methods of diagnosis.

  本文提供了包含偶氮基团的改性氨基酸，包括改性氨基酸的多肽、抗体和结合物，以及生产包含改性氨基酸的多肽、抗体和结合物的方法。这些多肽、抗体和结合物在治疗和预防方法、检测方法和诊断方法中非常有用。
• Lithium diorganocuprate reactions with l-serine derivatives
  作者：J.A. Bajgrowicz、A. El Hallaoui、R. Jacquier、Ch. Pigière、Ph. Viallefont

  DOI：10.1016/s0040-4039(01)81283-1

  日期：——

  The lithium diorganocuprate reactions with L-serine derivatives are studied. Retention of configuration, or at least a high enantiomeric excess (>80%) of the formed α-amino esters is observed in all cases. Attempts are made to restrict side-reactions.

  研究了L-丝氨酸衍生物的二有机十二酸锂反应。在所有情况下都观察到构型的保留，或至少高对映体过量（> 80％）的形成的α-氨基酯。试图限制副反应。
• Nucleotides for the treatment of cancer
  申请人：IDENIX PHARMACEUTICALS LLC

  公开号：US10766917B2

  公开（公告）日：2020-09-08

  The present invention relates to novel nucleoside derivatives, pharmaceutical compositions comprising the compounds, processes of preparation thereof, and methods of use thereof for treating cancer.

  本发明涉及新型核苷衍生物、包含这些化合物的药物组合物、其制备工艺以及用于治疗癌症的方法。
• INCORPORATION OF TWO DIFFERENT NONCANONICAL AMINO ACIDS INTO A SINGLE PROTEIN
  申请人：Liu Wenshe

  公开号：US20130078671A1

  公开（公告）日：2013-03-28

  The invention relates to methods, systems, and compositions for the genetic incorporation of a plurality of different noncanonical amino acids into one target protein. The invention provides for multiple, mutually orthogonal aminoacyl-tRNA synthetase/tRNA pairs that suppress two different selector codons engineered into a polynucleotide molecule. By virtue of the suppression of the selector codons, orthogonal aminoacyl-tRNA synthetase/tRNA pairs permit incorporation of their charged noncanonical amino acids into the corresponding positions in the protein. The noncanonical amino acids provide a wide array of functional capabilities. For example, the noncanonical amino acids can provide a reactive pair of moieties that facilitate the study and manipulation of the target protein.
• NUCLEOTIDES FOR THE TREATMENT OF CANCER
  申请人：IDENIX PHARMACEUTICALS LLC

  公开号：US20180155385A1

  公开（公告）日：2018-06-07

  The present invention relates to novel nucleoside derivatives, pharmaceutical compositions comprising the compounds, processes of preparation thereof, and methods of use thereof for treating cancer.