| 1187922-67-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• CAS: 1187922-67-3
• 化学式: C₂₇H₂₈N₂O₅S₂
• 分子量: 524.662
• InChiKey: RHHDLNUJTMGXDK-VWLOTQADSA-N

反应信息

• 作为产物：
  描述：

  对甲苯磺酰叠氮 、 以 四氢呋喃 、 异丙醇 为溶剂， 反应 2.0h， 生成
  参考文献：
  名称：

  An improved practical synthesis of protected α-amino selenocarboxylates and its application to the synthesis of N-(α-aminoacyl)sulfonamides

  摘要：

  An improved practical synthetic method was developed for the preparation of selenocarboxylates of amino acids through the reaction of the corresponding activated esters with sodium hydrogen selenide in alcoholic or aqueous medium. The protected cc-amino selenocarboxylates reacted readily with sulfonyl azide to form N-(alpha-aminoacyl)sulfonamides in high yields. The commonly used protecting groups in amino acid and peptide chemistries are well tolerated under these reaction conditions. No protecting groups are needed for the side chains of Arg, Met, Set, Tyr, and Trp. (C) 2009 Published by Elsevier Ltd.

  DOI：

  10.1016/j.tetlet.2009.07.080