1-(3-Bromophenyl)-3-methylcyclobutane-1-carbonitrile | 1342950-94-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-(3-Bromophenyl)-3-methylcyclobutane-1-carbonitrile
• CAS: 1342950-94-0
• 化学式: C₁₂H₁₂BrN
• 分子量: 250.13
• InChiKey: INSINJLJNPERGS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  23.8
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1-(3-Bromophenyl)-3-methylcyclobutane-1-carbonitrile 在 硫酸 、 水 、 一水合肼 、 溶剂黄146 作用下， 以 甲醇 为溶剂， 反应 50.25h， 生成 1-(3-bromophenyl)-3-methylcyclobutane-1-carbohydrazide
  参考文献：
  名称：

  SUBSTITUTED PYRIDINONE COMPOUNDS AS CBL-B INHIBITORS

  摘要：

  The present invention is directed to compounds of formula (I) and pharmaceutically acceptable salts thereof, which are useful as CBL-b inhibitors, processes for their preparation, pharmaceutical compositions comprising the compounds, and the use of the compounds or the compositions in the treatment or prevention of various diseases, conditions and/or disorders mediated by CBL-b.

  公开号：

  WO2024038378A1
• 作为产物：
  描述：

  1,3-二溴-2-甲基丙烷 、 3-溴氰苄 在 sodium hydride 作用下， 以 N,N-二甲基甲酰胺 、 mineral oil 为溶剂， 以9.15 g的产率得到1-(3-Bromophenyl)-3-methylcyclobutane-1-carbonitrile
  参考文献：
  名称：

  SUBSTITUTED PYRIDINONE COMPOUNDS AS CBL-B INHIBITORS

  摘要：

  The present invention is directed to compounds of formula (I) and pharmaceutically acceptable salts thereof, which are useful as CBL-b inhibitors, processes for their preparation, pharmaceutical compositions comprising the compounds, and the use of the compounds or the compositions in the treatment or prevention of various diseases, conditions and/or disorders mediated by CBL-b.

  公开号：

  WO2024038378A1

文献信息

• WO2024062363A1
  申请人：——

  公开号：——

  公开（公告）日：——
• [EN] HETEROCYCLIC COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH<br/>[FR] COMPOSÉS HÉTÉROCYCLIQUES, COMPOSITIONS DE CEUX-CI ET PROCÉDÉS DE TRAITEMENT ASSOCIÉS
  申请人：[en]BEIGENE , LTD.

  公开号：WO2023151641A1

  公开（公告）日：2023-08-17

  Provided herein are compounds having the following structure, wherein the substituents are as defined herein, compositions comprising an effective amount of a compound, and methods for modulating activity of an immune cell.
• SUBSTITUTED PYRIDINONE COMPOUNDS AS CBL-B INHIBITORS
  申请人：[en]GLENMARK PHARMACEUTICALS LTD

  公开号：WO2024038378A1

  公开（公告）日：2024-02-22

  The present invention is directed to compounds of formula (I) and pharmaceutically acceptable salts thereof, which are useful as CBL-b inhibitors, processes for their preparation, pharmaceutical compositions comprising the compounds, and the use of the compounds or the compositions in the treatment or prevention of various diseases, conditions and/or disorders mediated by CBL-b.