7,17-dihydroxy-docosa-4,8,15,19-tetraene-10,13-diynoic acid methyl ester | 1063609-49-3

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 7,17-dihydroxy-docosa-4,8,15,19-tetraene-10,13-diynoic acid methyl ester
• 英文别名: methyl (4Z,7S,8E,15E,17S,19Z)-7,17-dihydroxydocosa-4,8,15,19-tetraen-10,13-diynoate
• CAS: 1063609-49-3
• 化学式: C₂₃H₃₀O₄
• 分子量: 370.489
• InChiKey: ARKUDIWVMMCGRG-IDVNGHOQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  27
• 可旋转键数：
  11
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  66.8
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  7,17-dihydroxy-docosa-4,8,15,19-tetraene-10,13-diynoic acid methyl ester 在 氘代甲醇 、 重水 作用下， 生成 d4-Resolvin D5 methyl ester
  参考文献：
  名称：

  WO2008/118457

  摘要：

  公开号：

文献信息

• SYNTHESIS OF RESOLVINS AND INTERMEDIATES, COMPOUNDS PREPARED THEREBY, AND USES THEREOF
  申请人：Rodriguez Ana

  公开号：US20100159540A1

  公开（公告）日：2010-06-24

  Methods are disclosed for the preparation of a new class of lipid mediators known as resolvins, with Resolvin D6 (4,17-dihydroxy-5E,7Z,10Z,13Z,15E,19Z-docosahexaenoic acid) being exemplary. Also disclosed are methods for the efficient synthesis of key intermediates in the preparation of such resolvins, such as isotopically labeled ω-3 fatty acid metabolites, and derivatives and analogs thereof. The invention likewise extends to the intermediates so prepared, and to the resolvins prepared with their use.
• [EN] SYNTHESIS OF RESOLVINS AND INTERMEDIATES, COMPOUNDS PREPARED THEREBY, AND USES THEREOF<br/>[FR] SYNTHÈSE DE RÉSOLVINES ET D'INTERMÉDIAIRES, COMPOSÉS PRÉPARÉS PAR CETTE SYNTHÈSE ET LEURS UTILISATIONS
  申请人：UNIV NEW JERSEY MED

  公开号：WO2008118457A2

  公开（公告）日：2008-10-02

  [EN] Methods are disclosed for the preparation of a new class of lipid mediators known as resolvins, with Resolvin D6 (4,17-dihydroxy-5E,7Z,10Z,13Z,15E,19Z-docosahexaenoic acid) being exemplary. Also disclosed are methods for the efficient synthesis of key intermediates in the preparation of such resolvins, such as isotopically labeled ?-3 fatty acid metabolites, and derivatives and analogs thereof. The invention likewise extends to the intermediates so prepared, and to the resolvins prepared with their use.
  [FR] L'invention concerne des procédés de préparation d'une nouvelle classe de médiateurs lipides nommés résolvines, la résolvine D6 (acide 4,17-dihydroxy-5E,7Z,10Z,13Z,15E,19Z-docosahexaénoïque) en étant un exemple. L'invention concerne également des procédés efficaces de synthèse d'intermédiaires clés pour la préparation de telles résolvines, par exemple les métabolites d'acide gras ?-3 isotopiquement marqués et leurs dérivés et analogues. L'invention concerne également les intermédiaires ainsi préparés et les résolvines préparées en les utilisant.