{6-[4-Methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-ylmethoxy]-1H-indol-3-yl}-acetic acid | 600166-69-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: {6-[4-Methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-ylmethoxy]-1H-indol-3-yl}-acetic acid
• 英文别名: 2-[6-[[4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl]methoxy]-1H-indol-3-yl]acetic Acid
• CAS: 600166-69-6
• 化学式: C₂₂H₁₇F₃N₂O₃S
• 分子量: 446.45
• InChiKey: BITIJHCBOSLEOK-UHFFFAOYSA-N

物化性质

• 沸点：
  647.0±65.0 °C(Predicted)
• 密度：
  1.431±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  31
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  103
• 氢给体数：
  2
• 氢受体数：
  8

文献信息

• [EN] (5- (2-PHENYL)-THIAZOL-5-YLMETHOXY)-INDOL-1-YL) -ACETIC ACID DERIVATIVES AND RELATED COMPOUNDS AS MODULATORS OF THE HUMAN PPAR-DELTA RECEPTOR FOR THE TREATMENT OF METABOLIC DISORDERS SUCH AS TYPE 2 DIABETES<br/>[FR] DERIVES DE L'ACIDE (5- (2-PHENYL)-THIAZOL-5-YLMETHOXY)-INDOL-1-YL) -ACETIQUE ET COMPOSES ASSOCIES EN TANT QUE MODULATEURS DU RECEPTEUR PPAR-DELTA HUMAIN POUR LE TRAITEMENT DE TROUBLES METABOLIQUES TELS QUE LE DIABETE DE TYPE 2
  申请人：KALYPSYS INC

  公开号：WO2005060958A1

  公开（公告）日：2005-07-07

  Disclosed are compounds having the structure of Formula (I) and pharmaceutically acceptable salts and solvates thereof [A]-[B]-[C] (I) wherein (a) [A] is [H]-[L]; wherein [H] represents a CCOH (or a hydrolyzable ester thereof) or tetrazole group [L] is: formula (II), b) [B] is a ring system selected from the group consisting of: e.g. formula (III); (IIIA), c) [C] is e.g. formula (IV); the other substituents and variables are defined in the claims; as modulators of the human PPAR-delta receptor for the treatment of metabolic disorders such as type 2 diabetes.

  揭示了具有以下结构的化合物及其药学上可接受的盐和溶剂化合物[A]-[B]-[C] (I) 其中 (a) [A] 是 [H]-[L]; 其中 [H] 代表 CCOH (或其可水解酯) 或四唑基团 [L] 是：式 (II), b) [B] 是从以下群组中选择的环系统：例如式 (III); (IIIA), c) [C] 是例如式 (IV); 其他取代基和变量在权利要求中定义; 作为人类PPAR-δ受体的调节剂，用于治疗代谢性疾病，如2型糖尿病。
• Compounds that modulate PPAR activity and methods of preparation
  申请人：——

  公开号：US20030207915A1

  公开（公告）日：2003-11-06

  This invention discloses compounds that alter PPAR activity. The invention also discloses pharmaceutically acceptable salts of the compounds, pharmaceutically acceptable compositions comprising the compounds or their salts, and methods of using them as therapeutic agents for treating or preventing hyperlipidemia and hypercholesteremia in a mammal. The present invention also discloses method for making the disclosed compounds.

  这项发明揭示了能够改变PPAR活性的化合物。该发明还揭示了这些化合物的药用盐、包含这些化合物或其盐的药用组合物，以及将它们用作治疗或预防哺乳动物高脂血症和高胆固醇血症的治疗剂的方法。本发明还揭示了制备所述化合物的方法。
• SUBSTITUTED THIAZOLES AND OXAZOLES THAT MODULATE PPAR ACTIVITY
  申请人：WARNER-LAMBERT COMPANY

  公开号：EP1480641A1

  公开（公告）日：2004-12-01
• INDOLYL DERIVATIVES SUBSTITUTED WITH A THIAZOLE RING AND THEIR USE AS PPAR MODULATORS
  申请人：F. HOFFMANN-LA ROCHE AG

  公开号：EP1644368A1

  公开（公告）日：2006-04-12
• US6867224B2
  申请人：——

  公开号：US6867224B2

  公开（公告）日：2005-03-15