4,5,6,7-Tetrafluoro-L-tryptophan | 72120-72-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 4,5,6,7-Tetrafluoro-L-tryptophan
• 英文别名: (2S)-2-amino-3-(4,5,6,7-tetrafluoro-1H-indol-3-yl)propanoic acid
• CAS: 72120-72-0
• 化学式: C₁₁H₈F₄N₂O₂
• 分子量: 276.19
• InChiKey: TVKMKLHCZVODHW-BYPYZUCNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.9
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  79.1
• 氢给体数：
  3
• 氢受体数：
  7

文献信息

• COMPOUNDS AND METHODS FOR THE TREATMENT OF PAIN AND OTHER DISEASES
  申请人：Sucholeiki Irving

  公开号：US20110257222A1

  公开（公告）日：2011-10-20

  The present invention relates generally to alkyne containing pharmaceutical agents, and in particular, to phenylethynyl-thiophene based metalloprotease inhibitor compounds. More particularly, the present invention provides a new class of MMP inhibiting compounds that exhibit increased potency, metabolic stability and/or reduced toxicity in relation to currently known MMP inhibitors for the treatment of pain and other diseases such as cancer. Additionally, the present invention relates to methods for treating pain in a patient comprising administering to the patient a pain-reducing effective amount of a present compound.

  本发明通常涉及含炔基的药物，特别是基于苯基乙炔基硫苯基的金属蛋白酶抑制剂化合物。更具体地说，本发明提供了一种新型MMP抑制剂化合物，其在治疗疼痛和其他疾病（如癌症）方面表现出增强的效力、代谢稳定性和/或降低的毒性，相对于目前已知的MMP抑制剂。此外，本发明还涉及治疗患者疼痛的方法，包括向患者施用一种当前化合物的减痛有效量。
• NANOCOMPOSITES FOR IMAGING AND DRUG DELIVERY
  申请人：NUVOX PHARMA, LLC

  公开号：US20150250898A1

  公开（公告）日：2015-09-10

  A composition ( 100 ) which includes a shell ( 120 ) comprising at least one lipid, wherein said shell defines an enclosed space, a gas ( 110 ) disposed within the enclosed space, and a coating ( 130 ) of a polyalkylene glycol attached to and extending outwardly from lipid shell.
• US8765953B2
  申请人：——

  公开号：US8765953B2

  公开（公告）日：2014-07-01
• [EN] COMPOUNDS AND METHODS FOR THE TREATMENT OF PAIN AND OTHER DISEASES<br/>[FR] COMPOSÉS ET PROCÉDÉS POUR LE TRAITEMENT DE LA DOULEUR ET D'AUTRES MALADIES
  申请人：AQUILUS PHARMACEUTICALS INC

  公开号：WO2010075287A2

  公开（公告）日：2010-07-01

  The present invention relates generally to alkyne containing pharmaceutical agents, and in particular, to phenylethynyl-thiophene based metalloprotease inhibitor compounds. More particularly, the present invention provides a new class of MMP inhibiting compounds that exhibit increased potency, metabolic stability and/or reduced toxicity in relation to currently known MMP inhibitors for the treatment of pain and other diseases such as cancer. Additionally, the present invention relates to methods for treating pain in a patient comprising administering to the patient a pain-reducing effective amount of a present compound.
• [EN] NANOCOMPOSITES FOR IMAGING AND DRUG DELIVERY<br/>[FR] NANOCOMPOSITES POUR L'IMAGERIE ET L'ADMINISTRATION DE MÉDICAMENTS
  申请人：NUVOX PHARMA L L C

  公开号：WO2014047509A1

  公开（公告）日：2014-03-27

  A composition (100) which includes a shell (120) comprising at least one lipid, wherein said shell defines an enclosed space, a gas (110) disposed within the enclosed space, and a coating (130) of a polyalkylene glycol attached to and extending outwardly from lipid shell.