2-Acetylamino-4-phenyl-6-(3-phenyl-ureido)-pyrimidine-5-carboxylic acid ethyl ester | 134221-36-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 2-Acetylamino-4-phenyl-6-(3-phenyl-ureido)-pyrimidine-5-carboxylic acid ethyl ester
• CAS: 134221-36-6
• 化学式: C₂₂H₂₁N₅O₄
• 分子量: 419.44
• InChiKey: ALRRXQGXFARCRN-UHFFFAOYSA-N

反应信息

• 作为反应物：
  描述：

  2-Acetylamino-4-phenyl-6-(3-phenyl-ureido)-pyrimidine-5-carboxylic acid ethyl ester 在 sodium methylate 作用下， 以 甲醇 为溶剂， 反应 2.0h， 生成 7-amino-3,5-diphenyl-1H,3H-pyrimido<4,5-d>pyrimidine-2,4-dione
  参考文献：
  名称：

  Synthesis of 2,4-diamino-5-acetyl(ethoxycarbonyl)pyrimidines from ?-dicarbonyl compounds and dicyandiamide and their use for building a pyrimido[4,5-d]pyrimidine system

  摘要：

  2,4-Diamino-5-acetyl(ethoxycarbonyl)-6-methyl(phenyl)pyrimidines were obtained by the reaction of acetylacetone and beta-ketocarboxylic acid esters with dicyandiamide in the presence of Ni(OAc)2. It was shown that annelation of the pyrimidine ring with this compound provides a convenient method for building the pyrimido[4,5-d]-pyrimidine system. New derivatives of 2-aminopyrimido[4,5-d]pyrimidine, 7-amino-3H-pyrimido[4,5-d]-pyrimidin-4-one, and 7-amino-1H,3H-pyrimido[4,5-d]-pyrimidine-2,4-dione were synthesized.

  DOI：

  10.1007/bf00959646
• 作为产物：
  描述：

  苯甲酰乙酸乙酯 在 nickel diacetate 作用下， 以 甲苯 为溶剂， 反应 15.0h， 生成 2-Acetylamino-4-phenyl-6-(3-phenyl-ureido)-pyrimidine-5-carboxylic acid ethyl ester
  参考文献：
  名称：

  Synthesis of 2,4-diamino-5-acetyl(ethoxycarbonyl)pyrimidines from ?-dicarbonyl compounds and dicyandiamide and their use for building a pyrimido[4,5-d]pyrimidine system

  摘要：

  2,4-Diamino-5-acetyl(ethoxycarbonyl)-6-methyl(phenyl)pyrimidines were obtained by the reaction of acetylacetone and beta-ketocarboxylic acid esters with dicyandiamide in the presence of Ni(OAc)2. It was shown that annelation of the pyrimidine ring with this compound provides a convenient method for building the pyrimido[4,5-d]-pyrimidine system. New derivatives of 2-aminopyrimido[4,5-d]pyrimidine, 7-amino-3H-pyrimido[4,5-d]-pyrimidin-4-one, and 7-amino-1H,3H-pyrimido[4,5-d]-pyrimidine-2,4-dione were synthesized.

  DOI：

  10.1007/bf00959646