(R)-N-Methylpyrrolidine-3-carboxamide | 1160161-52-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (R)-N-Methylpyrrolidine-3-carboxamide
• 英文别名: (3R)-N-methylpyrrolidine-3-carboxamide
• CAS: 1160161-52-3
• 化学式: C₆H₁₂N₂O
• 分子量: 128.17
• InChiKey: BVOWXWSHDIGNRE-RXMQYKEDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.8
• 重原子数：
  9
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  41.1
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (R)-N-Methylpyrrolidine-3-carboxamide 、 2-Chloro-4-[3-(5-fluoropyrimidin-2-yl)-2-methoxyanilino]pyrimidine-5-carboxamide 在 N,N-二异丙基乙胺 作用下， 以 正丁醇 为溶剂， 以17 %的产率得到(R)-4-((3-(5-fluoropyrimidin-2-yl)-2-methoxyphenyl)amino)-2-(3-(methylcarbamoyl)pyrrolidin-1-yl)pyrimidine-5-carboxamide
  参考文献：
  名称：

  [EN] SUBSTITUTED PYRIMIDINE COMPOUNDS AS TYK2 INHIBITORS
  [FR] COMPOSÉS DE PYRIMIDINE SUBSTITUÉS EN TANT QU'INHIBITEURS DE TYK2

  摘要：

  Provided are TYK2 inhibitors of Formula I, processes for their production, their use as pharmaceuticals and pharmaceutical compositions comprising them. These compounds are useful, for example, in treating TYK2-mediated disorders, such as, autoimmune and inflammatory disorders, metabolic disorders, proliferative disorders, endocrine disorders,neurological disorders, allergic disorders, and disorders associated with transplantation.

  公开号：

  WO2024026430A1

文献信息

• SUBSTITUTED IMIDAZOHETEROCYCLES
  申请人：Beckett R. Paul

  公开号：US20090149450A1

  公开（公告）日：2009-06-11

  The present invention provides substituted imidazoheterocyclic compounds having the structure of formula I Also provided are pharmaceutically acceptable salts, acid salts, hydrates, solvates and stereoisomers of the compounds of formula I. The compounds are useful as modulators of cannabinoid receptors and for the prophylaxis and treatment of cannabinoid receptor-associated diseases and conditions, such as pain, inflammation and pruritis.

  本发明提供了具有公式I结构的取代咪唑杂环化合物，同时还提供了公式I化合物的药学上可接受的盐、酸盐、水合物、溶剂合物和立体异构体。该化合物可用作大麻素受体调节剂，并用于预防和治疗与大麻素受体相关的疾病和症状，例如疼痛、炎症和瘙痒等。
• PYRIDINYL SULFONAMIDE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF
  申请人：Boehringer Ingelheim International GmbH

  公开号：US20210353608A1

  公开（公告）日：2021-11-18

  The invention relates to new pyridinyl sulfonamide derivatives of the formula wherein R 1 , A and n are as defined herein, to their use as medicaments, to methods for their therapeutic use and to pharmaceutical compositions containing them.
• US8431565B2
  申请人：——

  公开号：US8431565B2

  公开（公告）日：2013-04-30