3-[(S)-2-Benzyloxycarbonylamino-2-((S)-1-benzyloxycarbonyl-pentylcarbamoyl)-ethyl]-indole-1-carboxylic acid benzyl ester | 148796-08-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 3-[(S)-2-Benzyloxycarbonylamino-2-((S)-1-benzyloxycarbonyl-pentylcarbamoyl)-ethyl]-indole-1-carboxylic acid benzyl ester
• CAS: 148796-08-1
• 化学式: C₄₀H₄₁N₃O₇
• 分子量: 675.781
• InChiKey: LGRCGCRCWSFFPT-PXLJZGITSA-N

物化性质

• 密度：
  1.20±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

反应信息

• 作为反应物：
  描述：

  3-[(S)-2-Benzyloxycarbonylamino-2-((S)-1-benzyloxycarbonyl-pentylcarbamoyl)-ethyl]-indole-1-carboxylic acid benzyl ester 在 喹啉 、 三(2-氯乙基)胺 、 五氯化磷 作用下， 生成 Z-Trp-(NⁱⁿZ)-Ψ-Nle-OBzl
  参考文献：
  名称：

  Tryptophan-containing 1,5-tetrazole dipeptide analogs: Synthesis of Trpψ[CN4]Nle as a cis amide bond surrogate.

  摘要：

  The 1,5-disubstituted tetrazole dipeptide analog Z-Trp(N(in)Z)PSI[CN4]Nle-OBzl was synthesized in good yield and high optical purity using a modified procedure of Zabrocki et al. This dipeptide analog can be selectively deprotected at either the N or the C terminal for further incorporation into peptides.

  DOI：

  10.1016/s0040-4039(00)60771-2
• 作为产物：
  描述：

  氯甲酸苄酯 、 (N^αZ)-Trp-Nle-OCH2Ph 在 potassium fluoride 、 18-冠醚-6 作用下， 生成 3-[(S)-2-Benzyloxycarbonylamino-2-((S)-1-benzyloxycarbonyl-pentylcarbamoyl)-ethyl]-indole-1-carboxylic acid benzyl ester
  参考文献：
  名称：

  Tryptophan-containing 1,5-tetrazole dipeptide analogs: Synthesis of Trpψ[CN4]Nle as a cis amide bond surrogate.

  摘要：

  The 1,5-disubstituted tetrazole dipeptide analog Z-Trp(N(in)Z)PSI[CN4]Nle-OBzl was synthesized in good yield and high optical purity using a modified procedure of Zabrocki et al. This dipeptide analog can be selectively deprotected at either the N or the C terminal for further incorporation into peptides.

  DOI：

  10.1016/s0040-4039(00)60771-2