methyl 7α-tert-butyldimethylsilyloxy-13-oxo-podocarp-8(14)-en-19-oate | 886846-34-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 菲及其衍生物
• 英文名称: methyl 7α-tert-butyldimethylsilyloxy-13-oxo-podocarp-8(14)-en-19-oate
• CAS: 886846-34-0
• 化学式: C₂₄H₄₀O₄Si
• 分子量: 420.665
• InChiKey: YMKSJXLDZJCXJU-QZVVCZJMSA-N

反应信息

• 作为产物：
  描述：

  methyl 7α-tert-butyldimethylsilyloxy-8,13-dioxo-14,15,17-trinorlabdan-19-oate 在 potassium carbonate 作用下， 以 甲醇 为溶剂， 反应 1.5h， 以78%的产率得到methyl 7α-tert-butyldimethylsilyloxy-13-oxo-podocarp-8(14)-en-19-oate
  参考文献：
  名称：

  A New Route toward 7-Oxo-13-hydroxy-8,11,13-podocarpatrienes from Labdane Diterpenes

  摘要：

  Trinorlabdane 1,5-diketones (7, 10a, b, 13a,b), which are easily prepared from labdane diterpenes, are directly converted into the corresponding 7-oxo-13-hydroxy-8,11,13-podocarpatrienes, immediate precursors of bioactive compounds, under basic treatment. Utilizing this strategy, the first enantiospecific synthesis of 13-hydroxy-8,11,13-podocarpatriene (20), a constituent of Taiwania cryptomerioides, was achieved starting from (-)- sclareol ( 5) after a seven-step sequence in 55% overall yield.

  DOI：

  10.1021/np0502847