1-(4-formyl-benzyl)-1H-indole-5-carboxylic acid amide | 865543-02-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 1-(4-formyl-benzyl)-1H-indole-5-carboxylic acid amide
• 英文别名: 1-[(4-Formylphenyl)methyl]indole-5-carboxamide
• CAS: 865543-02-8
• 化学式: C₁₇H₁₄N₂O₂
• 分子量: 278.31
• InChiKey: BMVYARUYRSIUJQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  65.1
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• [EN] 4- (5- (AMINOMETHYL) -INDOLE-1-YLMETHYL) -BENZAMIDE DERIVATIVES AND RELATED COMPOUNDS AS OPIOID RECEPTOR ANTAGONISTS FOR THE TREATMENT OF OBESITY<br/>[FR] DERIVES DE 4-(5-(AMINOMETHYL)-INDOLE-1-YLMETHYL)-BENZAMIDE ET COMPOSES ASSOCIES, UTILES COMME ANTAGONISTES DES RECEPTEURS OPIOIDES POUR TRAITER L'OBESITE
  申请人：LILLY CO ELI

  公开号：WO2005090303A1

  公开（公告）日：2005-09-29

  The present invention relates to compounds of formulae (I) and (II) useful as opioid receptor antagonists for the treatment of obesity, wherein p is 0, 1, or 2; y is 0, 1, or 2; and z is 0, 1, or 2; X1 is CH2, CH, or N; to form a indolinyl, indolyl, or benzimidazole ring respectively and including applicable double bonds and/or hydrogen atoms; X2 is CH or N; R1 to R7, R3', p, y, and z are as defined in the claims.

  本发明涉及化合物的公式(I)和(II)，用作阿片受体拮抗剂，用于治疗肥胖，其中p为0、1或2；y为0、1或2；z为0、1或2；X1为CH2、CH或N；分别形成吲哚基、吲哚基或苯并咪唑环，包括适用的双键和/或氢原子；X2为CH或N；R1至R7、R3'、p、y和z如索赔中定义的那样。
• 4-(5-AMINOMETHYL)-INDOLE-1-YLMETHYL)-BENZAMIDE DERIVATIVES AND RELATED COMPOUNDS AS OPIOID RECEPTOR ANTAGONISTS FOR THE TREATMENT OF OBESITY
  申请人：BENESH Rae Dana

  公开号：US20070155793A1

  公开（公告）日：2007-07-05

  The present invention relates to compounds of formulae (I) and (II) useful as opioid receptor antagonists for the treatment of obesity, wherein p is 0, 1, or 2; y is 0, 1, or 2; and z is 0, 1, or 2; X 1 is CH 2 , CH, or N; to form a indolinyl, indolyl, or benzimidazole ring respectively and including applicable double bonds and/or hydrogen atoms; X 2 is CH or N; R 1 to R 7 , R 3′ , p, y, and z are as defined in the claims.

  本发明涉及式（I）和（II）化合物，其作为阿片受体拮抗剂用于肥胖症的治疗，其中p为0、1或2；y为0、1或2；z为0、1或2；X1为CH2、CH或N；以形成吲哚啉基、吲哚基或苯并咪唑环，包括适用的双键和/或氢原子；X2为CH或N；R1至R7、R3'、p、y和z如权利要求所定义。
• 4-(5-(AMINOMETHYL)-INDOLE-1-YLMETHYL)-BENZAMIDE DERIVATIVES AND RELATED COMPOUNDS AS OPIOID RECEPTOR ANTAGONISTS FOR THE TREATMENT OF OBESITY
  申请人：ELI LILLY AND COMPANY

  公开号：EP1751103A1

  公开（公告）日：2007-02-14
• US8088800B2
  申请人：——

  公开号：US8088800B2

  公开（公告）日：2012-01-03