N,N'-methylenebis(2-methylpropanamide) | 13025-16-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N,N'-methylenebis(2-methylpropanamide)
• 英文别名: Bis-isobutyrylamino-methan；Bis-methan；2-methyl-N-[(2-methylpropanoylamino)methyl]propanamide
• CAS: 13025-16-6
• 化学式: C₉H₁₈N₂O₂
• 分子量: 186.254
• InChiKey: MGQVSPHRKFDCRU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.78
• 拓扑面积：
  58.2
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  Bis--ether 在 盐酸 作用下， 以 正庚烷 为溶剂， 生成 N,N'-methylenebis(2-methylpropanamide)
  参考文献：
  名称：

  Mosevich,I.K.; Arbusova,I.A., Journal of Organic Chemistry USSR (English Translation), 1968, vol. 4, # 10, p. 1664 - 1665

  摘要：

  DOI：

文献信息

• Mesoionic N‐Heterocyclic Imines as Super Nucleophiles in Catalytic Couplings of Amides with CO ₂
  作者：Arpan Das、Pallavi Sarkar、Subir Maji、Swapan K. Pati、Swadhin K. Mandal

  DOI：10.1002/anie.202213614

  日期：2022.12.19

  A series of mesoionic N-heterocyclic imine (mNHI) based superbases are introduced in this work. The mNHIs were utilized as metal-free catalysts in transformations using CO2 for the coupling of amides.

  本文介绍了一系列基于中离子 N-杂环亚胺 (mNHI) 的超级碱。mNHI 在使用 CO 2偶联酰胺的转化中用作无金属催化剂。
• BIFUNCTIONAL HISTONE DEACETYLASE INHIBITORS
  申请人：Bradner James Elliot

  公开号：US20090312363A1

  公开（公告）日：2009-12-17

  In recognition of the need to develop novel therapeutic agents and efficient methods for the synthesis thereof, the present invention provides novel bifunctional, trifunctional, or multifunctional compounds for inhibiting histone deacetylases, and pharmaceutically acceptable salts and derivatives thereof. The present invention further provides methods for treating disorders regulated by histone deacetylase activity (e.g., proliferative diseases, cancer, inflammatory diseases, protozoal infections, hair loss, etc.) comprising administering a therapeutically effective amount of an inventive compound to a subject in need thereof. The present invention also provides methods for preparing compounds of the invention.
• US8222423B2
  申请人：——

  公开号：US8222423B2

  公开（公告）日：2012-07-17
• US8754237B2
  申请人：——

  公开号：US8754237B2

  公开（公告）日：2014-06-17
• Mosevich,I.K.; Arbusova,I.A., Journal of Organic Chemistry USSR (English Translation), 1968, vol. 4, # 10, p. 1664 - 1665
  作者：Mosevich,I.K.、Arbusova,I.A.

  DOI：——

  日期：——