4-Hydroxy-2-hydroxymethylindol | 27748-18-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 4-Hydroxy-2-hydroxymethylindol
• 英文别名: 1H-Indole-2-methanol, 4-hydroxy-；2-(hydroxymethyl)-1H-indol-4-ol
• CAS: 27748-18-1
• 化学式: C₉H₉NO₂
• 分子量: 163.176
• InChiKey: GBVHBAQGRMFKIJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  56.2
• 氢给体数：
  3
• 氢受体数：
  2

文献信息

• EP1509515A4
  申请人：——

  公开号：EP1509515A4

  公开（公告）日：2006-07-05
• SUBSTITUTED 4-ARYL-4H-PYRROLO 2,3-H CHROMENES AND ANALOGS AS ACTIVATORS OF CASPASES AND INDUCERS OF APOPTOSIS AND THE USE THEREOF
  申请人：Cytovia, Inc.

  公开号：EP1509515A2

  公开（公告）日：2005-03-02
• [EN] SUBSTITUTED 4-ARYL-4H-PYRROLO[2,3-H]CHROMENES AND ANALOGS AS ACTIVATORS OF CASPASES AND INDUCERS OF APOPTOSIS AND THE USE THEREOF<br/>[FR] 4-ARYL-4H-PYRROLO[2,3-H]CHROMENES SUBSTITUES ET ANALOGUES EN TANT QU'ACTIVATEURS DE CASPASES ET INDUCTEURS D'APOPTOSE, ET LEUR UTILISATION
  申请人：CYTOVIA INC

  公开号：WO2003097806A2

  公开（公告）日：2003-11-27

  The present invention is directed to substituted 4H-chromenes and analogs thereof, represented by the Formula (I): wherein R1, R3-R5, A, D, Y and Z are defined herein. The present invention also relates to the discovery that compounds having Formula (I) are activators of caspases and inducers of apoptosis. Therefore, the activators of caspases and inducers of apoptosis of this invention can be used to induce cell death in a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.