6-Methyl-2-[6-(thien-2-yl)hexylamino]-4H-3,1-benzoxazin-4-one | 282530-70-5

• 分子结构分类: 有机化合物 - 有机杂环化合物
• 英文名称: 6-Methyl-2-[6-(thien-2-yl)hexylamino]-4H-3,1-benzoxazin-4-one
• 英文别名: 6-Methyl-2-(6-thiophen-2-ylhexylamino)-3,1-benzoxazin-4-one
• CAS: 282530-70-5
• 化学式: C₁₉H₂₂N₂O₂S
• 分子量: 342.462
• InChiKey: ZSZQPTPLWHGWKY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  24
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.37
• 拓扑面积：
  78.9
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• 2-amino-benzoxazinone derivatives for the treatment of obesity
  申请人：——

  公开号：US20030013707A1

  公开（公告）日：2003-01-16

  The use of a compound comprising formula (I): 1 (I) or a salt, ester, amide or prodrug therof in the inhibition of an enzyme whose preferred mode of action is to catalyse the hydrolysis of an ester functionality, e.g. in the control and inhibition of unwanted enzymes in products and processes. The compounds are also useful in medicine e.g. in the treatment of obesity and related conditions. The invention also relates to novel compounds within formula (I), to processes for preparing them and pharmaceutical compositions containing them. In formula (I) A is a 6-membered aromatic or heteroaromatic ring; and R 1 is a branched or unbranched alkyl (optionally interrupted by one or more oxygen atoms), alkenyl, alkynyl, cycloalkyl, cycloalkenyl, aryl, arylalkyl, reduced arylalkyl, arylalkenyl, heteroaryl, heteroarylalkyl, heteroarylalkenyl, reduced aryl, reduced heteroaryl, reduced heteroarylalkyl or a substituted derivative of any of the foregoing groups.

  使用化合物公式(I):1(I)或其盐、酯、酰胺或前药来抑制一种首选作用方式为催化酯官能团水解的酶的活性，例如在产品和过程中控制和抑制不需要的酶。该化合物在医学上也有用，例如在肥胖和相关疾病的治疗中。该发明还涉及公式(I)中的新化合物，制备它们的方法以及含有它们的药物组合物。在公式(I)中，A是6元芳香或杂芳香环；R1是支链或直链烷基（可以被一个或多个氧原子中断）、烯基、炔基、环烷基、环烯基、芳基、芳基烷基、还原芳基烷基、芳基烯基、杂芳基、杂芳基烷基、还原芳基、还原杂芳基烷基或任何上述基团的取代衍生物。
• [EN] 2-AMINO-4H-3,1-BENZOXAZIN-4-ONE DERIVATIVES FOR THE TREATMENT OF OBESITY<br/>[FR] 2-AMINO-4H-3,1-BENZOXAZINE-4-ONES DESTINEES AU TRAITEMENT DE L'OBESITE
  申请人：ALIZYME THERAPEUTICS LTD

  公开号：WO2000040247A1

  公开（公告）日：2000-07-13

  The use of a compound comprising formula (I) or a salt, ester, amide or prodrug therof in the inhibition of an enzyme whose preferred mode of action is to catalyse the hydrolysis of an ester functionality, e.g. in the control and inhibition of unwanted enzymes in products and processes. The compounds are also useful in medicine e.g. in the treatment of obesity and related conditions. The invention also relates to novel compounds within formula (I), to processes for preparing them and pharmaceutical compositions containing them. In formula (I) A is a 6-membered aromatic or heteroaromatic ring; and R1 is a branched or unbranched alkyl (optionally interrupted by one or more oxygen atoms), alkenyl, alkynyl, cycloalkyl, cycloalkenyl, aryl, arylalkyl, reduced arylalkyl, arylalkenyl, heteroaryl, heteroarylalkyl, heteroarylalkenyl, reduced aryl, reduced heteroaryl, reduced heteroarylalkyl or a substituted derivative of any of the foregoing groups.

  使用公式（I）或其盐、酯、酰胺或前药，以抑制一种首选作用模式是催化酯官能团水解的酶的活性，例如在产品和过程中控制和抑制不需要的酶。这些化合物还可用于医学，例如在肥胖和相关疾病的治疗中。本发明还涉及公式（I）内的新化合物，制备它们的过程以及含有它们的制药组合物。在公式（I）中，A是6元芳香或杂芳香环；R1是支链或直链烷基（可选地由一个或多个氧原子中断），烯基，炔基，环烷基，环烯基，芳基，芳基烷基，还原芳基烷基，芳基烯基，杂芳基，杂芳基烷基，还原芳基，还原杂芳基烷基或任何上述基团的取代衍生物。
• 2-OXY-BENZOXAZINONE DERIVATIVES FOR THE TREATMENT OF OBESITY
  申请人：Alizyme Therapeutics Limited

  公开号：EP1143977A1

  公开（公告）日：2001-10-17
• 2-AMINO-BENZOXAZINONE DERIVATIVES FOR THE TREATMENT OF OBESITY
  申请人：Alizyme Therapeutics Limited

  公开号：EP1144395B1

  公开（公告）日：2005-04-20
• US6656934B2
  申请人：——

  公开号：US6656934B2

  公开（公告）日：2003-12-02