(2,3-二甲基苯基)氯化镁 | 146741-81-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: (2,3-二甲基苯基)氯化镁
• 英文名称: (2,3-dimethylphenyl)magnesium chloride
• CAS: 146741-81-3
• 化学式: C₈H₉ClMg
• 分子量: 164.917
• InChiKey: SADDAWAHJLQMRW-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  1.79
• 重原子数：
  10.0
• 可旋转键数：
  1.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  0.0
• 氢给体数：
  0.0
• 氢受体数：
  0.0

反应信息

• 作为反应物：
  描述：

  (2,3-二甲基苯基)氯化镁 在 iron(III) chloride 1,2-二氯丙烷 作用下， 以 四氢呋喃 为溶剂， 反应 3.0h， 生成 2,2',3,3'-四甲基联苯
  参考文献：
  名称：

  METHOD FOR PRODUCING A BIPHENYL DERIVATIVE

  摘要：

  公开号：

  EP2075241B1
• 作为产物：
  描述：

  3-氯-邻-二甲苯 、 magnesium 在 溴乙烷 、 叔丁基氯化镁 作用下， 以 四氢呋喃 为溶剂， 反应 3.0h， 生成 (2,3-二甲基苯基)氯化镁
  参考文献：
  名称：

  METHOD FOR PRODUCING A BIPHENYL DERIVATIVE

  摘要：

  公开号：

  EP2075241B1

文献信息

• Production processes for triorganomonoalkoxysilanes and triorganomonochlorosilanes
  申请人：Bannou Tadashi

  公开号：US20050070730A1

  公开（公告）日：2005-03-31

  A silane containing a bulky hydrocarbon group or groups R therein and having the formula (III) R 3-(x+y) (R 1 ) x (R 2 ) y Si(OR 3 ) can be produced by reacting a silane of the formula (I) (R 1 ) x (R 2 ) y SiCl 3-(x+y) (OR 3 ) with a Grignard reagent of the formula (II) RMgX Further, a tri-organo-chlorosilane of the formula (XIIa) (R 1 )(R 2 )(R 3 )SiCl can be produced by reacting a tri-organo-silane of the formula (XIa) (R 1 )(R 2 )(R 3 )SiZ 1 with hydrochloric acid. Furthermore, a tri-organo-monoalkoxysilane of the formula (XXIII) R 3-(x+y) (R 1 ) x (R 2 ) y Si(OR 3 ) can be produced when a silane of the formula (XXI) (R 1 ) x (R 2 ) y SiCl 4-(x+y) is reacted with a Grignard reagent of the formula (XXII) RMgX with addition of and reaction with an alcohol or an epoxy compound during the reaction.

  含有庞大烃基或基团R的硅烷，其具有式(III)R3-(x+y)(R1)x(R2)ySi(OR3)，可通过反应式(I)(R1)x(R2)ySiCl3-(x+y)(OR3)的硅烷与式(II)RMgX的格氏试剂制得。此外，式(XIIa)(R1)(R2)(R3)SiCl的三有机氯硅烷可通过反应式(XIa)(R1)(R2)(R3)SiZ1的三有机硅烷与盐酸制得。再者，当式(XXI)(R1)x(R2)ySiCl4-(x+y)的硅烷与式(XXII)RMgX的格氏试剂反应，并在反应过程中加入并反应酒精或环氧化合物时，可制得式(XXIII)R3-(x+y)(R1)x(R2)ySi(OR3)的三有机单烷氧基硅烷。
• Bioinspired Total Synthesis and Human Proteasome Inhibitory Activity of (−)-Salinosporamide A, (−)-Homosalinosporamide A, and Derivatives Obtained via Organonucleophile Promoted Bis-cyclizations
  作者：Henry Nguyen、Gil Ma、Tatiana Gladysheva、Trisha Fremgen、Daniel Romo

  DOI：10.1021/jo101638r

  日期：2011.1.7

  bis-cyclization of a β-keto tertiary amide, which retains optical purity enabled by A1,3-strain rendering slow epimerization relative to the rate of bis-cyclization. Optimization studies of the key bis-cyclization, enabled through byproduct isolation and characterization, are described that ultimately allowed for a gram scale synthesis of a versatile bicyclic core structure with a high degree of stereoretention

  受生物合成考虑的启发，描述了抗癌剂 (−)-salinosporamide A 及其衍生物（包括 (−)-homosalinosporamide）的简明、对映选择性合成的完整说明。合成策略的简洁性源于 β-酮叔酰胺的关键双环化，它保留了由 A 1,3菌株实现的光学纯度，从而相对于双环化速率呈现缓慢的差向异构化。描述了通过副产物分离和表征实现的关键双环化的优化研究，最终实现了具有高度立体保留的通用双环核心结构的克级合成。通过 Knochel 方法生成锌酸盐的优化程序通常用于合成 salino A 衍生物，导致侧链连接的显着改善和 salino A 的新型非对映异构体。合成证明了所述策略的多功能性设计的衍生物包括 (−)-homosalinosporamide A。还报道了使用酶法测定这些衍生物对人 20S 和 26S 蛋白酶体的抑制。所描述的盐A全合成提出了有趣的问题，即生物合成酶如何通过光
• PROCESSES FOR THE PRODUCTION OF TRI-ORGANO-MONOALKOXYSILANES AND PROCESS FOR THE PRODUCTION OF TRI-ORGANO-MONOCHLOROSILANES
  申请人：Bannou Tadashi

  公开号：US20090082585A1

  公开（公告）日：2009-03-26

  A silane containing a bulky hydrocarbon group or groups R therein and having the formula (III) R 3−(x+y) (R 1 ) x (R 2 ) y Si(OR 3 ) can be produced by reacting a silane of the formula (I) (R 1 ) x (R 2 ) y SiCl 3−(x+y) (OR 3 ) with a Grignard reagent of the formula (II) RMgX Further, a tri-organo-chlorosilane of the formula (XIIa) (R 1 )(R 2 )(R 3 )SiCl can be produced by reacting a tri-organo-silane of the formula (XIa) (R 1 )(R 2 )(R 3 )SiZ 1 with hydrochloric acid. Furthermore, a tri-organo-monoalkoxysilane of the formula (XXIII) R 3−(x+y) (R 1 ) x (R 2 ) y Si(OR 3 ) can be produced when a silane of the formula (XXI) (R 1 ) x (R 2 ) y SiCl 4−(x+y) is reacted with a Grignard reagent of the formula (XXII) RMgX with addition of and reaction with an alcohol or an epoxy compound during the reaction.

  含有笨重烃基团R的硅烷化合物，其化学式为(III)R3−(x+y)(R1)x(R2)ySi(OR3)，可以通过将化学式为(I)(R1)x(R2)ySiCl3−(x+y)(OR3)的硅烷与化学式为(II)RMgX的格氏试剂反应来制备。此外，可以通过将化学式为(XIa)(R1)(R2)(R3)SiZ1的三元有机硅烷与盐酸反应来制备化学式为(XIIa)(R1)(R2)(R3)SiCl的三元有机氯硅烷。此外，在反应过程中加入醇或环氧化合物，可以通过将化学式为(XXI)(R1)x(R2)ySiCl4−(x+y)的硅烷与化学式为(XXII)RMgX的格氏试剂反应来制备化学式为(XXIII)R3−(x+y)(R1)x(R2)ySi(OR3)的三元有机单烷氧基硅烷。
• TRANSITION METAL COMPLEX
  申请人：Sumitomo Chemical Company, Limited

  公开号：US20150105572A1

  公开（公告）日：2015-04-16

  Disclosed is transition metal complex that serves as a catalytic component with which 1-hexene can be produced efficiently with excellent selectivity, even under high temperature conditions, by means of an ethylene trimerization reaction. Said transition metal complex is represented by the following general formula (1), wherein M 1 represents a Group 4 transition metal atom, and R 1 through R 11 and X 1 through X 3 each independently represent a hydrogen atom, a halogen atom, or a specific organic group.

  本发明涉及一种过渡金属配合物，该配合物可作为催化组分，在乙烯三聚反应中，即使在高温条件下，也能高效地选择性地生产1-己烯。所述过渡金属配合物由下述一般式（1）表示，其中M1表示4族过渡金属原子，R1至R11和X1至X3各自独立地表示氢原子、卤素原子或特定的有机基团。
• CATALYTIC COMPONENT FOR TRIMERIZATION AND TRIMERIZATION CATALYST
  申请人：Sumitomo Chemical Company, Limited

  公开号：US20150105237A1

  公开（公告）日：2015-04-16

  Disclosed is a catalytic component for trimerization containing a transition metal complex with which 1-hexene can be produced efficiently with excellent selectivity, even under high temperature conditions, by means of an ethylene trimerization reaction. Also disclosed is a trimerization catalyst that is obtained by bringing an olefin copolymerization catalyst and an activating co-catalytic component into contact with one another. Said transition metal complex is represented by the following general formula (1), wherein M 1 represents a Group 4 transition metal atom, and R 1 through R 11 and X 1 through X 3 each independently represent a hydrogen atom, a halogen atom, or a specific organic group.

  本发明揭示了一种催化三聚化的催化成分，其中包含一种过渡金属配合物，通过乙烯三聚化反应，即使在高温条件下，也能高效地选择性地生产1-己烯。还揭示了一种三聚化催化剂，其是通过使烯烃共聚催化剂和活化共催化成分相互接触而获得的。所述过渡金属配合物由下述一般式（1）表示，其中M1表示第4族过渡金属原子，R1至R11和X1至X3各自独立地表示氢原子、卤素原子或特定的有机基团。