5-Methoxy-7-chlortryptamin | 3703-88-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 5-Methoxy-7-chlortryptamin
• 英文别名: 2-(7-chloro-5-methoxy-indol-3-yl)-ethylamine；5-Methoxy-7-chlorotryptamine；2-(7-chloro-5-methoxy-1H-indol-3-yl)ethanamine
• CAS: 3703-88-6
• 化学式: C₁₁H₁₃ClN₂O
• 分子量: 224.69
• InChiKey: CJTGXISAJWEXQZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  51
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• CDKI pathway inhibitors as inhibitors of tumor cell growth
  申请人：Chang Bey-Dih

  公开号：US20080200531A1

  公开（公告）日：2008-08-21

  The invention provides new methods for inhibiting the CDKI pathway and specifically inhibiting tumor cell growth. The invention further provides new and specific inhibitors of tumor cell growth, as well as means for discovery of additional such inhibitors. The present inventors have surprisingly discovered that Cyclin-Dependent Kinase 3 (CDK3) is specifically required for tumor cell growth, in contrast to other members of the CDK family.
• [EN] CDKI PATHWAY INHIBITORS AS SELECTIVE INHIBITORS OF TUMOR CELL GROWTH<br/>[FR] INHIBITEURS DE LA VOIE DES CDKI UTILISÉS EN TANT QU'INHIBITEURS SÉLECTIFS DE LA CROISSANCE DES CELLULES TUMORALES
  申请人：SENEX BIOTECHNOLOGY INC

  公开号：WO2007133772A2

  公开（公告）日：2007-11-22

  [EN] The invention provides new methods for inhibiting the CDKI pathway and specifically inhibiting tumor cell growth. The invention further provides new and specific inhibitors of tumor cell growth, as well as means for discovery of additional such inhibitors. The present inventors have surprisingly discovered that Cyclin-Dependent Kinase 3 (CDK3) is specifically required for tumor cell growth, in contrast to other members of the CDK family.
  [FR] Cette invention concerne des nouvelles méthodes pour inhiber la voie des CDKI et plus spécifiquement pour inhiber la croissance des cellules tumorales. Cette invention concerne également des nouveaux inhibiteurs de la croissance des cellules tumorales spécifiques, ainsi que des moyens permettant de découvrir d'autres inhibiteurs identiques. Par rapport aux autres membres de la famille des CDK, la kinase 3 dépendante des cyclines 3 (CDK3) s'est révélée être plus particulièrement utile pour la croissance des cellules tumorales.