3-(Pyridin-2-yl)-1H-pyrazolo[3,4-b]pyridine | 918485-24-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡唑并吡啶类
• 英文名称: 3-(Pyridin-2-yl)-1H-pyrazolo[3,4-b]pyridine
• 英文别名: 3-pyridin-2-yl-2H-pyrazolo[3,4-b]pyridine
• CAS: 918485-24-2
• 化学式: C₁₁H₈N₄
• 分子量: 196.21
• InChiKey: SQDHRGOORALEHW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  54.5
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Pyrazolopyridine derivates
  申请人：Almansa Rosales Carmen

  公开号：US20060167040A1

  公开（公告）日：2006-07-27

  New compounds of formula (I) and the salts, solvates and prodrugs thereof, wherein the meanings for the various substituents are as disclosed in the description. These compounds are useful as p38 kinase inhibitors.

  新化合物的公式为（I），以及其盐，溶剂合物和前药，其中各种取代基的含义如描述所示。这些化合物可用作p38激酶抑制剂。
• Pyrazolopyridine Derivates
  申请人：Almansa Rosales Carmen

  公开号：US20090005377A1

  公开（公告）日：2009-01-01

  New compounds of formula (I) and the salts thereof, wherein the meanings for the various substituents are as disclosed in the description, are useful as p38 kinase inhibitors.

  公式（I）及其盐的新化合物，其中各取代基的含义如说明中所披露，可用作p38激酶抑制剂。
• AZAINDAZOLE COMPOUNDS AND METHODS OF USE
  申请人：Zhang Penglie

  公开号：US20080058341A1

  公开（公告）日：2008-03-06

  Compounds are provided that act as potent antagonists of the CCR1 receptor, and have in vivo anti-inflammatory activity. The compounds are generally aryl piperazine derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR1-mediated diseases, and as controls in assays for the identification of competitive CCR1 antagonists.

  提供了一些化合物，它们作为CCR1受体的有效拮抗剂，并具有体内抗炎活性。这些化合物通常是芳基哌嗪衍生物，可用于制备药物组合物、治疗CCR1介导的疾病的方法，以及作为竞争性CCR1拮抗剂鉴定的控制试剂。
• Azaindazole compounds and methods of use
  申请人：Zhang Penglie

  公开号：US20070010524A1

  公开（公告）日：2007-01-11

  Compounds are provided that act as potent antagonists of the CCR1 receptor, and have in vivo anti-inflammatory activity. The compounds are generally aryl piperazine derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR1-mediated diseases, and as controls in assays for the identification of competitive CCR1 antagonists.

  提供了化合物，它们作为CCR1受体的有效拮抗剂，并具有体内抗炎活性。这些化合物通常是芳基哌嗪衍生物，可用于制备药物组合物，用于治疗CCR1介导的疾病的方法，并作为竞争性CCR1拮抗剂鉴定的控制。
• PYRAZOLE DERIVATIVES AS KINASE INHIBITORS
  申请人：Pellecchia Maurizio

  公开号：US20090124621A1

  公开（公告）日：2009-05-14

  The present invention provides compounds having the general structure I, or a pharmaceutically acceptable salt thereof: wherein X is a six-member ring selected from phenyl, pyridine, or pyrimidine; Y is H, an alkenyl, a substituted alkenyl, or alkynyl, and R is H or alkyl. Pharmaceutical compositions for treating various disorders such as cancers, the compositions including compound I are also provided.