(1S,2R,3R,5R)-3-(hydroxymethyl)-5-[[2-(2-methoxyethylamino)-5-[2-(6-methoxypyridin-3-yl)ethynyl]-6-methylpyrimidin-4-yl]amino]cyclopentane-1,2-diol | 1208108-70-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: (1S,2R,3R,5R)-3-(hydroxymethyl)-5-[[2-(2-methoxyethylamino)-5-[2-(6-methoxypyridin-3-yl)ethynyl]-6-methylpyrimidin-4-yl]amino]cyclopentane-1,2-diol
• CAS: 1208108-70-6
• 化学式: C₂₂H₂₉N₅O₅
• 分子量: 443.503
• InChiKey: LUFMPUYANGIZPS-QOJCHSLYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  32
• 可旋转键数：
  10
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  142
• 氢给体数：
  5
• 氢受体数：
  10

文献信息

• ETHYNYL-SUBSTITUTED PYRIDINE AND PYRIMIDINE DERIVATIVES AND THEIR USE IN TREATING VIRAL INFECTIONS
  申请人：Kwong Cecil D.

  公开号：US20120107271A1

  公开（公告）日：2012-05-03

  The present invention provides compounds of Formula (I): (Chemical formula should be inserted here as it appears on abstract in paper form) (I) and tautomers, isomers, and esters of said compounds, and pharmaceutically acceptable salts, solvates, and pro-drugs of said compounds, wherein each of R, R 1 , X, Y, Z, R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , R 18 , R 19 and n is selected independently and as defined herein. Compositions comprising such compounds are also provided. The compounds of the invention are effective as inhibitors of HCV, and are useful, alone and together with other therapeutic agents, in treating or preventing diseases or disorders such as viral infections and virus-related disorders.
• US8541434B2
  申请人：——

  公开号：US8541434B2

  公开（公告）日：2013-09-24