| 1357265-73-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• CAS: 1357265-73-6
• 化学式: C₂₃H₄₅N₃O₅
• 分子量: 443.627
• InChiKey: NOEASBRIXRVAAN-NRFANRHFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.03
• 重原子数：
  31.0
• 可旋转键数：
  19.0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.87
• 拓扑面积：
  127.76
• 氢给体数：
  5.0
• 氢受体数：
  5.0

反应信息

• 作为产物：
  描述：

  (4R)-N-(3-((2-dodecanamidoethyl)amino)-3-oxopropyl)-2-(4-methoxyphenyl)-5,5-dimethyl-1,3-dioxane-4-carboxamide 在 盐酸 作用下， 以 四氢呋喃 、 水 为溶剂， 反应 1.0h， 以78%的产率得到
  参考文献：
  名称：

  Resin-based investigation of acyl carrier protein interaction networks in Escherichia coli

  摘要：

  Protein-protein interactions play an integral role in metabolic regulation. Elucidation of these networks is complicated by the changing identity of the proteins themselves. Here we demonstrate a resin-based technique that leverages the unique tools for acyl carrier protein (ACP) modification with non-hydrolyzable linkages. ACPs from Escherichia coli and Shewanella oneidensis MR-1 are bound to Affigel-15 with varying acyl groups attached and introduced to proteomic samples. Isolation of these binding partners is followed by MudPIT analysis to identify each interactome with the variable of ACP-tethered substrates. These techniques allow for investigation of protein interaction networks with the changing identity of a given protein target. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2011.10.053