| 1225292-06-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• CAS: 1225292-06-7
• 化学式: C₂₂H₄₀O₈
• 分子量: 432.555
• InChiKey: IDXFISUYONPVIC-XADLVBFUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  30.0
• 可旋转键数：
  20.0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.77
• 拓扑面积：
  81.68
• 氢给体数：
  0.0
• 氢受体数：
  8.0

反应信息

• 作为产物：
  描述：

  methyl (4E,6S,7R,9Z)-6,7-dihydroxy-3-(methoxymethoxy)pentadeca-4,9-dienoate 、 氯甲基甲基醚 在 N,N-二异丙基乙胺 作用下， 生成
  参考文献：
  名称：

  Synthesis of the 1,2-Anti Type of 3E-Alkene-1,2,5-triol Derivatives

  摘要：

  We invented an efficient method to obtain 3E-alkene-1,2,5-triol derivatives with 1,2-anti stereochemistry from the 2Z,4E-alkadienyl alcohol derivatives, which were synthesized by using nickel-catalyzed coupling between lithium 1E-alkenyl borates and 1-halo-1Z-alken-3-ols. The method involves (1) asymmetric dihydroxylation at the E olefin moiety of the dienyl alcohol derivatives followed by formation of a cyclic carbonates; (2) palladium-catalyzed reaction with AcOH in the presence of Et(3)N. The method was applied successfully to the synthesis of the C6-C20 part of trioxilin A(3).

  DOI：

  10.3987/com-09-s(s)89