7-((E)-3-Phenyl-allyloxy)-heptan-1-ol | 700865-86-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 7-((E)-3-Phenyl-allyloxy)-heptan-1-ol
• CAS: 700865-86-7
• 化学式: C₁₆H₂₄O₂
• 分子量: 248.365
• InChiKey: QLLPFDHWPQTHSH-FMIVXFBMSA-N

物化性质

• 沸点：
  386.5±35.0 °C(Predicted)
• 密度：
  0.994±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.66
• 重原子数：
  18.0
• 可旋转键数：
  10.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  29.46
• 氢给体数：
  1.0
• 氢受体数：
  2.0

反应信息

• 作为反应物：
  描述：

  7-((E)-3-Phenyl-allyloxy)-heptan-1-ol 在 对甲苯磺酰叠氮 、 sodium acetate 、 三乙胺 作用下， 以 四氢呋喃 、 乙腈 为溶剂， 反应 12.0h， 生成 Diazo-acetic acid 7-((E)-3-phenyl-allyloxy)-heptyl ester
  参考文献：
  名称：

  Highly Selective Intra- and Intermolecular Coupling Reactions of Diazo Compounds to Form cis-Alkenes Using a Ruthenium Porphyrin Catalyst

  摘要：

  [Ru(2,6-Cl2TPP)(CO)] catalyzed intramolecular coupling reactions of bisdiazoacetates and intermolecular coupling reactions of monodiazoacetates to afford the coupling products in up to 76% and 93% yields, respectively. Only the cis isomers were obtained from the reactions. Employing such a ruthenium-catalyzed coupling reaction of a diazo compound as a key step allowed the synthesis of Patulolide B in 67% yield with a ratio of >40:1 against its trans isomer.

  DOI：

  10.1021/ol049626a
• 作为产物：
  描述：

  1,7-庚二醇 、 Cinnamyl bromide 在 sodium hydride 作用下， 以 四氢呋喃 为溶剂， 反应 6.0h， 以84%的产率得到7-((E)-3-Phenyl-allyloxy)-heptan-1-ol
  参考文献：
  名称：

  Highly Selective Intra- and Intermolecular Coupling Reactions of Diazo Compounds to Form cis-Alkenes Using a Ruthenium Porphyrin Catalyst

  摘要：

  [Ru(2,6-Cl2TPP)(CO)] catalyzed intramolecular coupling reactions of bisdiazoacetates and intermolecular coupling reactions of monodiazoacetates to afford the coupling products in up to 76% and 93% yields, respectively. Only the cis isomers were obtained from the reactions. Employing such a ruthenium-catalyzed coupling reaction of a diazo compound as a key step allowed the synthesis of Patulolide B in 67% yield with a ratio of >40:1 against its trans isomer.

  DOI：

  10.1021/ol049626a