(4R)-4-methyl-2-(7-nitro-1H-indol-2-yl)-4,5-dihydro-1,3-thiazole | 1120346-16-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: (4R)-4-methyl-2-(7-nitro-1H-indol-2-yl)-4,5-dihydro-1,3-thiazole
• CAS: 1120346-16-8
• 化学式: C₁₂H₁₁N₃O₂S
• 分子量: 261.304
• InChiKey: SNPOVMWKNOJQDS-SSDOTTSWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  18
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  99.3
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• INDOLE AND INDAZOLE DERIVATIVES HAVING A CELL-, TISSUE- AND ORGAN-PRESERVING EFFECT
  申请人：LG Life Sciences Ltd.

  公开号：EP2230238A2

  公开（公告）日：2010-09-22

  The present invention relates to a composition for preserving cells, tissues and organs, comprising as an active ingredient indole and indazole compounds of formula (1), or a pharmaceutically acceptable salt or isomer thereof, which are effective for preventing injury of organs, isolated cell systems or tissues caused by cold storage, transplant operation or post-transplantation reperfusion; a preservation method; and a preparation method of the composition.

  本发明涉及一种用于保存细胞、组织和器官的组合物，其活性成分包括式（1）的吲哚和吲唑化合物或其药学上可接受的盐或异构体，可有效防止冷藏、移植手术或移植后再灌注对器官、离体细胞系统或组织造成的损伤；一种保存方法；以及该组合物的制备方法。
• GLUCOKINASE ACTIVATORS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AS AN ACTIVE INGREDIENT
  申请人：LG Life Sciences Ltd.

  公开号：EP2220081A2

  公开（公告）日：2010-08-25
• [EN] GLUCOKINASE ACTIVATORS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AS AN ACTIVE INGREDIENT<br/>[FR] ACTIVATEURS DE LA GLUCOKINASE ET COMPOSITIONS PHARMACEUTIQUES CONTENANT CES DERNIERS EN TANT QU'INGRÉDIENT ACTIF
  申请人：LG LIFE SCIENCES LTD

  公开号：WO2009082152A2

  公开（公告）日：2009-07-02

  The present invention relates to new compounds of formula (1) exhibiting excellent activity for glucokinase, and pharmaceutical compositions comprising the same as an active ingredient.