DL-2-amino-5-guanidovaleric acid | 81200-79-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: DL-2-amino-5-guanidovaleric acid
• 英文别名: (2S)-2-amino-5-(diaminomethylideneazaniumyl)pentanoate;hydrate
• CAS: 81200-79-5
• 化学式: C6H16N4O3
• 分子量: 192.22
• InChiKey: JVDHWXLTNDKLIZ-WCCKRBBISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.37
• 重原子数：
  13
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  129
• 氢给体数：
  5
• 氢受体数：
  5

文献信息

• Use of selectively moisture-adjusted tabletting material in the production of mechanically stable tablets which contain at least one hydrate-forming active substance and/or adjuvant relevant to the mechanical stability of the tablets, particularly arginine-containing tablets
  申请人：BUSL Maria

  公开号：US20140100236A1

  公开（公告）日：2014-04-10

  The present invention relates inter alia to the use of selectively moisture-adjusted tabletting material in the preparation of mechanically stable oral tablets which contain at least one hydrate-forming active substance and/or adjuvant relevant to the mechanical stability of the tablets, particularly arginine-containing oral tablets.

  本发明涉及选择性调节水分的压片材料在制备机械稳定的口服片剂中的应用，所述口服片剂含有至少一种水合物形成的活性物质和/或有助于片剂机械稳定性的辅料，特别是含有精氨酸的口服片剂。
• [EN] BASIC SALTS AND MONOHYDRATES OF CERTAIN ALPHA, BETA-PROPRIONIC ACID DERIVATIVE<br/>[FR] SELS DE BASE ET MONOHYDRATES DE CERTAINS DERIVES D'ACIDE ALPHA, BETA-PROPRIONIQUE
  申请人：REDDYS LAB LTD DR

  公开号：WO2006001795A1

  公开（公告）日：2006-01-05

  The invention provides novel salts of (S)-2-methoxy-3-[4-3-(4-methanesulfonyloxyphenyl)propylamino}phenyl] proprionic acid, including Arginine salt of (S)-2-methoxy-3-[4-3-(4-methanesulfonyloxyphenyl)propilamino}phenyl] proprionic acid monohydrate, Arginine salt of (S)-2-methoxy-3-[4-3-(4-methanesulfonyloxyphenyl)propylamino}phenyl] proprionic acid, and (S)-2-methoxy-3-[4-3-(4-methanesulfonyloxyphenyl)propylamino}phenyl] proprionic acid monohydrate. Various aspects and embodiments are included. Compositions containing novel salts of (S)-2-methoxy-3-[4-3-(4-methanesulfonyloxyphenyl)propylamino}phenyl] proprionic acid are also provided.

  本发明提供了(S)-2-甲氧基-3-[4-3-(4-甲磺酰氧苯基)丙基氨基}苯基]丙酸的新型盐，包括(S)-2-甲氧基-3-[4-3-(4-甲磺酰氧苯基)丙基氨基}苯基]丙酸精氨酸盐单水合物、(S)-2-甲氧基-3-[4-3-(4-甲磺酰氧苯基)丙基氨基}苯基]丙酸精氨酸盐和(S)-2-甲氧基-3-[4-3-(4-甲磺酰氧苯基)丙基氨基}苯基]丙酸单水合物。本发明还包括各种方面和实施例。本发明还提供了含有(S)-2-甲氧基-3-[4-3-(4-甲磺酰氧苯基)丙基氨基}苯基]丙酸新型盐的组合物。
• Basic salts and monohydrates of certain alpha, beta-propionic acid derivative
  申请人：Palle Venkata Raghavendra Charyulu

  公开号：US20050277693A1

  公开（公告）日：2005-12-15

  The invention provides novel salts of (S)-2-methoxy-3-[4-3-(4-methanesulfonyloxyphenyl)propylamino} phenyl] propionic acid, including Arginine salt of (S)-2-methoxy-3-[4-3-(4-methanesulfonyloxyphenyl)propylamino} phenyl] propionic acid monohydrate, Arginine salt of (S)-2-methoxy-3-[4-3-(4-methanesulfonyloxyphenyl) propylamino} phenyl] propionic acid, and (S)-2-methoxy-3-[4-3-(4-methanesulfonyloxyphenyl)propylamino} phenyl] propionic acid monohydrate. Various aspects and embodiments are included. Compositions containing novel salts of (S)-2-methoxy-3-[4-3-(4-methanesulfonyloxyphenyl) propylamino}phenyl] propionic acid are also provided.

  本发明提供了(S)-2-甲氧基-3-[4-3-(4-甲烷磺酰氧苯基)丙基氨基}苯基]丙酸的新型盐，包括(S)-2-甲氧基-3-[4-3-(4-甲烷磺酰氧苯基)丙基氨基}苯基]丙酸单水合物的精氨酸盐，(S)-2-甲氧基-3-[4-3-(4-甲烷磺酰氧苯基)丙基氨基}苯基]丙酸的精氨酸盐，以及(S)-2-甲氧基-3-[4-3-(4-甲烷磺酰氧苯基)丙基氨基}苯基]丙酸单水合物。包括各种方面和实施例。还提供了含有(S)-2-甲氧基-3-[4-3-(4-甲烷磺酰氧苯基)丙基氨基}苯基]丙酸新型盐的组合物。
• Method of producing crystals of L-arginine phosphate monohydrate
  申请人：Philips Electronics N.V.

  公开号：EP0239146A1

  公开（公告）日：1987-09-30

  Large flow free crystals of L-arginine phosphate monohydrate (LAP) are produced from a saturated aqueous solution of LAP by rotating seed crystals of LAP in the solution while maintaining the pH of the solution at 2-8, preferably at 2-3 while lowering the temperature of the solution at a rate of 0.01°C-1°C until crystalliza­tion is completed.

  通过旋转溶液中的 LAP 种子晶体，同时将溶液的 pH 值保持在 2-8，最好是 2-3，并以 0.01°C-1°C 的速度降低溶液的温度，直到结晶完成，就可以从 LAP 的饱和水溶液中制备出 L-精氨酸磷酸一水合物（LAP）的大型无流动结晶。
• Preparation of 5,8,13,14-tetrahydrobenz(5,6)isoindolo (2,1-b)isoquinolin-8,13-dione derivatives
  申请人：GLAXO GROUP LIMITED

  公开号：EP0323907A2

  公开（公告）日：1989-07-12

  A process is described for the preparation of compounds of formula (1) [where OR is hydroxyl, protected hydroxyl or OP(O)(OCH₂Ph)(OR¹) (where Ph is phenyl and OR¹ is hydroxyl or protected hydroxyl)] and salts thereof, which comprises reacting a compound of formula (2) with a compound of formula (3) (where OR is as defined above and one of X¹ and X² is a leaving group and the other is a hydrogen atom) or a salt thereof, followed, if desired, by removal of the hydroxyl protecting group when present and/or by salt formation. The compounds of formula (1) are either anticancer agents or intermediates useful in the synthesis of anticancer agents.

  描述了一种制备式（1）化合物的工艺 [其中 OR 是羟基、受保护的羟基或 OP(O)(OCH₂Ph)(OR¹)（其中 Ph 是苯基，OR¹ 是羟基或受保护的羟基）]及其盐的工艺，包括将式（2）化合物 与式 (3) (其中 OR 如上定义，X¹ 和 X² 中的一个为离去基团，另一个为氢原子）或其盐反应，然后，如果需要，去除存在的羟基保护基和/或形成盐。 式（1）化合物可以是抗癌剂，也可以是用于合成抗癌剂的中间体。